Selective detection and transport of fully matched DNA by DNA-loaded microtubule and kinesin motor protein

Shu Taira, Yong Zhong Du, Yuichi Hiratsuka, Kaoru Konishi, Tai Kubo, Taro Q.P. Uyeda, Noboru Yumoto, Masato Kodaka

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

DNA-loaded microtubules (MTs) moving on a kinesin motor protein-coated substrate can selectively hybridize with a target fully matched DNA over single-base mismatched DNA and transport it. This technique is capable of collecting target biomolecules toward one point site to design new methodology of DNA analysis.

Original languageEnglish
Pages (from-to)533-538
Number of pages6
JournalBiotechnology and bioengineering
Volume95
Issue number3
DOIs
Publication statusPublished - 2006 Oct 20
Externally publishedYes

Keywords

  • DNA-loaded microtubules
  • Motor protein
  • SNP

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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