Self-assembling DNA-peptide hybrids

Morphological consequences of oligonucleotide grafting to a pathogenic amyloid fibrils forming dipeptide

Nidhi Gour, Dawid Kedracki, Ilyès Safir, Kien Xuan Ngo, Corinne Vebert-Nardin

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

For the very first time, highly efficient synthesis of DNA-peptide hybrids to scaffold self-assembled nanostructures is described. Oligonucleotide conjugation to the diphenylalanine dipeptide triggers a morphological transition from fibrillar to vesicular structures which may potentially be used as delivery vehicles, since they exhibit pH triggered release.

Original languageEnglish
Pages (from-to)5440-5442
Number of pages3
JournalChemical Communications
Volume48
Issue number44
DOIs
Publication statusPublished - 2012 Jun 4
Externally publishedYes

Fingerprint

Dipeptides
Oligonucleotides
Scaffolds (biology)
Amyloid
Scaffolds
Peptides
Nanostructures
DNA
diphenylalanine

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Self-assembling DNA-peptide hybrids : Morphological consequences of oligonucleotide grafting to a pathogenic amyloid fibrils forming dipeptide. / Gour, Nidhi; Kedracki, Dawid; Safir, Ilyès; Ngo, Kien Xuan; Vebert-Nardin, Corinne.

In: Chemical Communications, Vol. 48, No. 44, 04.06.2012, p. 5440-5442.

Research output: Contribution to journalArticle

Gour, Nidhi ; Kedracki, Dawid ; Safir, Ilyès ; Ngo, Kien Xuan ; Vebert-Nardin, Corinne. / Self-assembling DNA-peptide hybrids : Morphological consequences of oligonucleotide grafting to a pathogenic amyloid fibrils forming dipeptide. In: Chemical Communications. 2012 ; Vol. 48, No. 44. pp. 5440-5442.
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