Self-assembling DNA-peptide hybrids: Morphological consequences of oligonucleotide grafting to a pathogenic amyloid fibrils forming dipeptide

Nidhi Gour, Dawid Kedracki, Ilyès Safir, Kien Xuan Ngo, Corinne Vebert-Nardin

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

For the very first time, highly efficient synthesis of DNA-peptide hybrids to scaffold self-assembled nanostructures is described. Oligonucleotide conjugation to the diphenylalanine dipeptide triggers a morphological transition from fibrillar to vesicular structures which may potentially be used as delivery vehicles, since they exhibit pH triggered release.

Original languageEnglish
Pages (from-to)5440-5442
Number of pages3
JournalChemical Communications
Volume48
Issue number44
DOIs
Publication statusPublished - 2012 Jun 4
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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