Self-calibrated fluorescent thermometer nanoparticles enable in vivo micro thermography in milimeter scale living animals

Ferdinandus, Satoshi Arai, Shin'Ichi Ishiwata, Madoka Suzuki, Hirotaka Sato

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

We have developed a fluorescent nanoparticle thermometer capable of mapping out the temperature distributions in small animals with higher spatial resolution than conventional infrared thermography. To acquire the fluorescence intensity change solely owing to the temperature shift, we encapsulated both the thermo-sensitive dye and the thermo-insensitive (reference) dye into the nanoparticles. The nanoparticle thermometer exhibited a significantly high thermo-sensitivity of 3.6 %/°C, and could be orally dosed into fruit fly larvae so as to stably measure the temperature distributions in the animals. This thermal-microscopy system could provide a powerful experimental paradigm to illuminate physiological functions and activities in small living organisms.

Original languageEnglish
Title of host publication2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2228-2231
Number of pages4
ISBN (Print)9781479989553
DOIs
Publication statusPublished - 2015 Aug 5
Event18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 - Anchorage, United States
Duration: 2015 Jun 212015 Jun 25

Other

Other18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
CountryUnited States
CityAnchorage
Period15/6/2115/6/25

Keywords

  • fluorescence ratiometry
  • fluorescent nanoparticles
  • Thermal microscopy
  • thermography
  • thermometer nanoparticles

ASJC Scopus subject areas

  • Instrumentation
  • Electrical and Electronic Engineering

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    Ferdinandus, Arai, S., Ishiwata, SI., Suzuki, M., & Sato, H. (2015). Self-calibrated fluorescent thermometer nanoparticles enable in vivo micro thermography in milimeter scale living animals. In 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 (pp. 2228-2231). [7181404] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/TRANSDUCERS.2015.7181404