Self-complementary peptides for the formation of collagen-like triple helical supramolecules

Takaki Koide, Daisuke L. Homma, Shinichi Asada, Kouki Kitagawa

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Collagen is acknowledged as one of the most prominent biomaterials on account of its high biocompatibility and biostability. The development of artificial collagens to replace the animal-derived collagens presents a challenge in the formation of safer and highly functionalized biomaterials. Here, a novel peptide-based system for obtaining collagen-like supramolecules via a spontaneous self-assembling process is described. The designed collagen-like peptides are self-complementary trimers in which each of the 24-mer peptide strands is tethered by two cystine knots forming a staggered arrangement. Their self-assembling ability in aqueous solution was analyzed by circular dichroism, ultrafiltration, and laser diffraction particle size estimation. The obtained results indicate that the staggered trimers form large supramolecular architectures through intermolecular triple helix-formation.

Original languageEnglish
Pages (from-to)5230-5233
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number23
DOIs
Publication statusPublished - 2005 Dec 1
Externally publishedYes

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Keywords

  • Collagen
  • Peptide
  • Supramolecule
  • Triple helix

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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