Self-oscillating gel as novel biomimetic materials

Ryo Yoshida, Takamasa Sakai, Yusuke Hara, Shingo Maeda, Shuji Hashimoto, Daisuke Suzuki, Yoko Murase

    Research output: Contribution to journalArticlepeer-review

    49 Citations (Scopus)

    Abstract

    Stimuli-responsive polymers and their application to biomaterials have been widely studied. On the other hand, as a novel biomimetic polymer, we have been studying the polymer with an autonomous self-oscillating function by utilizing oscillating chemical reactions. So far, we succeeded in developing a novel self-oscillating polymer and gels by utilizing the oscillating reaction, called the Belousov-Zhabotinsky (BZ) reaction, which is recognized as a chemical model for understanding several autonomous phenomena in biological systems. The self-oscillating polymer is composed of poly(N-isopropylacrylamide) (PNIPAAm) network in which the catalyst for the BZ reaction is covalently immobilized. Under the coexistence of the reactants, the polymer undergoes spontaneous cyclic soluble-insoluble changes or swelling-deswelling changes (in the case of gel) without any on-off switching of external stimuli. In this paper, our recent studies on the self-oscillating polymer gels and the design of functional material systems using the polymer are summarized.

    Original languageEnglish
    Pages (from-to)186-193
    Number of pages8
    JournalJournal of Controlled Release
    Volume140
    Issue number3
    DOIs
    Publication statusPublished - 2009 Dec 16

    Keywords

    • Biomimetics
    • Polymer gels
    • Self-oscillation
    • Smart materials

    ASJC Scopus subject areas

    • Pharmaceutical Science

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