Self-referential processing of negative stimuli within the ventral anterior cingulate gyrus and right amygdala

Shinpei Yoshimura, Kazutaka Ueda, Shinichi Suzuki, Keiichi Onoda, Yasumasa Okamoto, Shigeto Yamawaki

    Research output: Contribution to journalArticle

    91 Citations (Scopus)

    Abstract

    Neural activity associated with self-referential processing of emotional stimuli was investigated using whole brain functional magnetic resonance imaging (fMRI). Fifteen healthy subjects underwent fMRI scanning while making judgments about positive and negative trait words in four conditions (self-reference, other-reference, semantic processing, and letter processing). Significant activity was observed in the right ventral anterior cingulate gyrus and the right amygdala in the negative-word/self-reference condition, and in the left amygdala in the positive-word/self-reference condition. Compared with the semantic-processing condition, the self-reference conditions showed significantly more activity in the medial prefrontal and temporal gyri, posterior cingulate gyrus, and precuneus. These results suggest that the medial prefrontal gyrus, posterior cingulate gyrus, and precuneus are associated with a self-referential processing, and the ventral anterior cingulate gyrus is involved in self-referential processing of negative emotional stimuli. The results also suggest that the amygdala is associated with self-referential processing of both positive and negative emotional stimuli.

    Original languageEnglish
    Pages (from-to)218-225
    Number of pages8
    JournalBrain and Cognition
    Volume69
    Issue number1
    DOIs
    Publication statusPublished - 2009 Feb

    Fingerprint

    Gyrus Cinguli
    Amygdala
    Parietal Lobe
    Semantics
    Magnetic Resonance Imaging
    Temporal Lobe
    Healthy Volunteers
    Referential Processing
    Self-reference
    Stimulus
    Brain
    Emotion
    Semantic Processing
    Functional Magnetic Resonance Imaging

    Keywords

    • Emotion
    • fMRI
    • Medial prefrontal gyrus
    • Self-reference effect

    ASJC Scopus subject areas

    • Cognitive Neuroscience
    • Experimental and Cognitive Psychology
    • Neuropsychology and Physiological Psychology

    Cite this

    Self-referential processing of negative stimuli within the ventral anterior cingulate gyrus and right amygdala. / Yoshimura, Shinpei; Ueda, Kazutaka; Suzuki, Shinichi; Onoda, Keiichi; Okamoto, Yasumasa; Yamawaki, Shigeto.

    In: Brain and Cognition, Vol. 69, No. 1, 02.2009, p. 218-225.

    Research output: Contribution to journalArticle

    Yoshimura, Shinpei ; Ueda, Kazutaka ; Suzuki, Shinichi ; Onoda, Keiichi ; Okamoto, Yasumasa ; Yamawaki, Shigeto. / Self-referential processing of negative stimuli within the ventral anterior cingulate gyrus and right amygdala. In: Brain and Cognition. 2009 ; Vol. 69, No. 1. pp. 218-225.
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    AU - Okamoto, Yasumasa

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