Self-referential processing of negative stimuli within the ventral anterior cingulate gyrus and right amygdala

Shinpei Yoshimura, Kazutaka Ueda, Shin ichi Suzuki, Keiichi Onoda, Yasumasa Okamoto, Shigeto Yamawaki

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Neural activity associated with self-referential processing of emotional stimuli was investigated using whole brain functional magnetic resonance imaging (fMRI). Fifteen healthy subjects underwent fMRI scanning while making judgments about positive and negative trait words in four conditions (self-reference, other-reference, semantic processing, and letter processing). Significant activity was observed in the right ventral anterior cingulate gyrus and the right amygdala in the negative-word/self-reference condition, and in the left amygdala in the positive-word/self-reference condition. Compared with the semantic-processing condition, the self-reference conditions showed significantly more activity in the medial prefrontal and temporal gyri, posterior cingulate gyrus, and precuneus. These results suggest that the medial prefrontal gyrus, posterior cingulate gyrus, and precuneus are associated with a self-referential processing, and the ventral anterior cingulate gyrus is involved in self-referential processing of negative emotional stimuli. The results also suggest that the amygdala is associated with self-referential processing of both positive and negative emotional stimuli.

Original languageEnglish
Pages (from-to)218-225
Number of pages8
JournalBrain and Cognition
Volume69
Issue number1
DOIs
Publication statusPublished - 2009 Feb

Keywords

  • Emotion
  • Medial prefrontal gyrus
  • Self-reference effect
  • fMRI

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Cognitive Neuroscience

Fingerprint Dive into the research topics of 'Self-referential processing of negative stimuli within the ventral anterior cingulate gyrus and right amygdala'. Together they form a unique fingerprint.

  • Cite this