Abstract
Methamphetamine (MAP) was administered to rats through drinking water repeatedly (three sessions, one session:administration for 60 days followed by withdrawal of 30 days) in order to examine whether or not MAP-induced disorganization of daily activity rhythm is sensitized. Each session (60 days) was divided into six blocks of 10 days. In the 1st session, daily locomotor activity rhythm of rats became disorganized around at 40 days (4th block) after the start of MAP drinking. However, MAP-induced disorganization of daily activity rhythm appeared at 20 days (2nd block) in the 2nd session and at 10 days (1st block) in the 3rd session following re-start of MAP drinking. On the other hand, the amount of MAP intake was decreased on the 2nd and 3rd sessions as compared with the 1st session. These results indicate that the mechanism of MAP-induced disorganization of daily activity rhythm may involve sensitization. Copyright (C) 1999 Elsevier Science B.V.
| Original language | English |
|---|---|
| Pages (from-to) | 112-116 |
| Number of pages | 5 |
| Journal | Brain Research |
| Volume | 845 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1999 Oct 16 |
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Keywords
- Circadian rhythm
- Methamphetamine
- Sensitization
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Sensitization of methamphetamine-induced disorganization of daily locomotor activity rhythm in male rats. / Nikaido, Takato; Moriya, Takahiro; Takabayashi, Reiko; Akigama, Masashi; Shibata, Shigenobu.
In: Brain Research, Vol. 845, No. 1, 16.10.1999, p. 112-116.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sensitization of methamphetamine-induced disorganization of daily locomotor activity rhythm in male rats
AU - Nikaido, Takato
AU - Moriya, Takahiro
AU - Takabayashi, Reiko
AU - Akigama, Masashi
AU - Shibata, Shigenobu
PY - 1999/10/16
Y1 - 1999/10/16
N2 - Methamphetamine (MAP) was administered to rats through drinking water repeatedly (three sessions, one session:administration for 60 days followed by withdrawal of 30 days) in order to examine whether or not MAP-induced disorganization of daily activity rhythm is sensitized. Each session (60 days) was divided into six blocks of 10 days. In the 1st session, daily locomotor activity rhythm of rats became disorganized around at 40 days (4th block) after the start of MAP drinking. However, MAP-induced disorganization of daily activity rhythm appeared at 20 days (2nd block) in the 2nd session and at 10 days (1st block) in the 3rd session following re-start of MAP drinking. On the other hand, the amount of MAP intake was decreased on the 2nd and 3rd sessions as compared with the 1st session. These results indicate that the mechanism of MAP-induced disorganization of daily activity rhythm may involve sensitization. Copyright (C) 1999 Elsevier Science B.V.
AB - Methamphetamine (MAP) was administered to rats through drinking water repeatedly (three sessions, one session:administration for 60 days followed by withdrawal of 30 days) in order to examine whether or not MAP-induced disorganization of daily activity rhythm is sensitized. Each session (60 days) was divided into six blocks of 10 days. In the 1st session, daily locomotor activity rhythm of rats became disorganized around at 40 days (4th block) after the start of MAP drinking. However, MAP-induced disorganization of daily activity rhythm appeared at 20 days (2nd block) in the 2nd session and at 10 days (1st block) in the 3rd session following re-start of MAP drinking. On the other hand, the amount of MAP intake was decreased on the 2nd and 3rd sessions as compared with the 1st session. These results indicate that the mechanism of MAP-induced disorganization of daily activity rhythm may involve sensitization. Copyright (C) 1999 Elsevier Science B.V.
KW - Circadian rhythm
KW - Methamphetamine
KW - Sensitization
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U2 - 10.1016/S0006-8993(99)01955-1
DO - 10.1016/S0006-8993(99)01955-1
M3 - Article
C2 - 10529451
AN - SCOPUS:0032842973
VL - 845
SP - 112
EP - 116
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -