Sensitization of methamphetamine-induced disorganization of daily locomotor activity rhythm in male rats

Takato Nikaido; Takahiro Moriya; Reiko Takabayashi; Masashi Akigama; Shigenobu Shibata

doi:10.1016/S0006-8993(99)01955-1

Sensitization of methamphetamine-induced disorganization of daily locomotor activity rhythm in male rats

Takato Nikaido, Takahiro Moriya, Reiko Takabayashi, Masashi Akigama, Shigenobu Shibata^*

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Methamphetamine (MAP) was administered to rats through drinking water repeatedly (three sessions, one session:administration for 60 days followed by withdrawal of 30 days) in order to examine whether or not MAP-induced disorganization of daily activity rhythm is sensitized. Each session (60 days) was divided into six blocks of 10 days. In the 1st session, daily locomotor activity rhythm of rats became disorganized around at 40 days (4th block) after the start of MAP drinking. However, MAP-induced disorganization of daily activity rhythm appeared at 20 days (2nd block) in the 2nd session and at 10 days (1st block) in the 3rd session following re-start of MAP drinking. On the other hand, the amount of MAP intake was decreased on the 2nd and 3rd sessions as compared with the 1st session. These results indicate that the mechanism of MAP-induced disorganization of daily activity rhythm may involve sensitization. Copyright (C) 1999 Elsevier Science B.V.

Original language	English
Pages (from-to)	112-116
Number of pages	5
Journal	Brain Research
Volume	845
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(99)01955-1
Publication status	Published - 1999 Oct 16

Keywords

Circadian rhythm
Methamphetamine
Sensitization

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(99)01955-1

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title = "Sensitization of methamphetamine-induced disorganization of daily locomotor activity rhythm in male rats",

abstract = "Methamphetamine (MAP) was administered to rats through drinking water repeatedly (three sessions, one session:administration for 60 days followed by withdrawal of 30 days) in order to examine whether or not MAP-induced disorganization of daily activity rhythm is sensitized. Each session (60 days) was divided into six blocks of 10 days. In the 1st session, daily locomotor activity rhythm of rats became disorganized around at 40 days (4th block) after the start of MAP drinking. However, MAP-induced disorganization of daily activity rhythm appeared at 20 days (2nd block) in the 2nd session and at 10 days (1st block) in the 3rd session following re-start of MAP drinking. On the other hand, the amount of MAP intake was decreased on the 2nd and 3rd sessions as compared with the 1st session. These results indicate that the mechanism of MAP-induced disorganization of daily activity rhythm may involve sensitization. Copyright (C) 1999 Elsevier Science B.V.",

keywords = "Circadian rhythm, Methamphetamine, Sensitization",

author = "Takato Nikaido and Takahiro Moriya and Reiko Takabayashi and Masashi Akigama and Shigenobu Shibata",

note = "Funding Information: This study was supported by grants to S.S. from the Japanese Ministry of Education, Science, Sports and culture (09470018).",

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AU - Akigama, Masashi

AU - Shibata, Shigenobu

N1 - Funding Information: This study was supported by grants to S.S. from the Japanese Ministry of Education, Science, Sports and culture (09470018).

PY - 1999/10/16

Y1 - 1999/10/16

N2 - Methamphetamine (MAP) was administered to rats through drinking water repeatedly (three sessions, one session:administration for 60 days followed by withdrawal of 30 days) in order to examine whether or not MAP-induced disorganization of daily activity rhythm is sensitized. Each session (60 days) was divided into six blocks of 10 days. In the 1st session, daily locomotor activity rhythm of rats became disorganized around at 40 days (4th block) after the start of MAP drinking. However, MAP-induced disorganization of daily activity rhythm appeared at 20 days (2nd block) in the 2nd session and at 10 days (1st block) in the 3rd session following re-start of MAP drinking. On the other hand, the amount of MAP intake was decreased on the 2nd and 3rd sessions as compared with the 1st session. These results indicate that the mechanism of MAP-induced disorganization of daily activity rhythm may involve sensitization. Copyright (C) 1999 Elsevier Science B.V.

AB - Methamphetamine (MAP) was administered to rats through drinking water repeatedly (three sessions, one session:administration for 60 days followed by withdrawal of 30 days) in order to examine whether or not MAP-induced disorganization of daily activity rhythm is sensitized. Each session (60 days) was divided into six blocks of 10 days. In the 1st session, daily locomotor activity rhythm of rats became disorganized around at 40 days (4th block) after the start of MAP drinking. However, MAP-induced disorganization of daily activity rhythm appeared at 20 days (2nd block) in the 2nd session and at 10 days (1st block) in the 3rd session following re-start of MAP drinking. On the other hand, the amount of MAP intake was decreased on the 2nd and 3rd sessions as compared with the 1st session. These results indicate that the mechanism of MAP-induced disorganization of daily activity rhythm may involve sensitization. Copyright (C) 1999 Elsevier Science B.V.

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Sensitization of methamphetamine-induced disorganization of daily locomotor activity rhythm in male rats

Abstract

Keywords

ASJC Scopus subject areas

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