Sensory cortex wiring requires preselection of short- and long-range projection neurons through an Egr-Foxg1-COUP-TFI network

Pei Shan Hou, Goichi Miyoshi, Carina Hanashima

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The bimodal requisite for a genetic program and external stimuli is a key feature of sensory circuit formation. However, the contribution of cell-intrinsic codes to directing sensory-specific circuits remains unknown. Here, we identify the earliest molecular program that preselects projection neuron types in the sensory neocortex. Mechanistically, Foxg1 binds to an H3K4me1-enriched enhancer site to repress COUP-TFI, where ectopic acquisition of Foxg1 in layer 4 cells transforms local projection neurons to callosal projection neurons with pyramidal morphologies. Removal of Foxg1 in long-range projection neurons, in turn, derepresses COUP-TFI and activates a layer 4 neuron-specific program. The earliest segregation of projection subtypes is achieved through repression of Foxg1 in layer 4 precursors by early growth response genes, the major targets of the transforming growth factor-β signaling pathway. These findings describe the earliest cortex-intrinsic program that restricts neuronal connectivity in sensory circuits, a fundamental step towards the acquisition of mammalian perceptual behavior.

Original languageEnglish
Article number3581
JournalNature communications
Volume10
Issue number1
DOIs
Publication statusPublished - 2019 Dec 1

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wiring
cortexes
Electric wiring
neurons
Neurons
projection
Corpus Callosum
Pyramidal Cells
Neocortex
Transforming Growth Factors
Sensory Receptor Cells
Networks (circuits)
acquisition
cells
genes
stimuli
Growth
Genes

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Sensory cortex wiring requires preselection of short- and long-range projection neurons through an Egr-Foxg1-COUP-TFI network. / Hou, Pei Shan; Miyoshi, Goichi; Hanashima, Carina.

In: Nature communications, Vol. 10, No. 1, 3581, 01.12.2019.

Research output: Contribution to journalArticle

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