Sequence analysis of a Kpnl family member near the 3′ end of human β-globin gene

Masahira Hattori, Saburo Hidaka, Yoshiyuki Sakaki

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

We determined the complete nucleotide sequence (6125 bp) of a full-length member of human KpnI family, designated TβG41, which is located about 3 kb downstream from the β-globin gene. Comparison of the sequence with the KpnI family sequence compiled by Singer revealed that a new 131 bp sequence is present in the TβG41. Hybridization analyses showed that a few thousand of human KpnI family members are carrying this additional sequence. Computer search of DNA databases for TβG41-homologous sequence showed that some TβG41-homologous sequences were closely associated with pseudogenes. The TβG41 sequence also showed significant sequence homology with ChBlyml, a transferrin-like transforming gene of chicken. Furthermore, an amino acid sequence deduced from the TβG41 nucleotide sequence revealed a relatively-high homology to those of human transferrin and lactotransferrin.

Original languageEnglish
Pages (from-to)7813-7827
Number of pages15
JournalNucleic Acids Research
Volume13
Issue number21
DOIs
Publication statusPublished - 1985 Nov 11
Externally publishedYes

Fingerprint

Globins
Sequence Analysis
Transferrin
Sequence Homology
Nucleotides
Genes
Gene
Lactoferrin
Amino acids
Pseudogenes
DNA
Nucleic Acid Databases
Oncogenes
Amino Acids
Amino Acid Sequence
Chickens
Homology
Human
Family
Sequence analysis

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Genetics(clinical)
  • Genetics

Cite this

Sequence analysis of a Kpnl family member near the 3′ end of human β-globin gene. / Hattori, Masahira; Hidaka, Saburo; Sakaki, Yoshiyuki.

In: Nucleic Acids Research, Vol. 13, No. 21, 11.11.1985, p. 7813-7827.

Research output: Contribution to journalArticle

Hattori, Masahira ; Hidaka, Saburo ; Sakaki, Yoshiyuki. / Sequence analysis of a Kpnl family member near the 3′ end of human β-globin gene. In: Nucleic Acids Research. 1985 ; Vol. 13, No. 21. pp. 7813-7827.
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