Sequence analysis of a Kpnl family member near the 3′ end of human β-globin gene

Masahira Hattori, Saburo Hidaka, Yoshiyuki Sakaki

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

We determined the complete nucleotide sequence (6125 bp) of a full-length member of human KpnI family, designated TβG41, which is located about 3 kb downstream from the β-globin gene. Comparison of the sequence with the KpnI family sequence compiled by Singer revealed that a new 131 bp sequence is present in the TβG41. Hybridization analyses showed that a few thousand of human KpnI family members are carrying this additional sequence. Computer search of DNA databases for TβG41-homologous sequence showed that some TβG41-homologous sequences were closely associated with pseudogenes. The TβG41 sequence also showed significant sequence homology with ChBlyml, a transferrin-like transforming gene of chicken. Furthermore, an amino acid sequence deduced from the TβG41 nucleotide sequence revealed a relatively-high homology to those of human transferrin and lactotransferrin.

Original languageEnglish
Pages (from-to)7813-7827
Number of pages15
JournalNucleic Acids Research
Volume13
Issue number21
DOIs
Publication statusPublished - 1985 Nov 11
Externally publishedYes

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Genetics(clinical)
  • Genetics

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