Matsumura et al. show that γIMCs sequentially sense group A Streptococcus (GAS) through TLR2 and Mincle. Specifically, TLR2-triggered production of IL-6 functions as an intermediate that amplifies Mincle expression to maximize host protection through IFN-γ production. The sequential sensing is a distinct feature in γIMCs following severe invasive GAS infection.
- C-type lectin receptors
- Toll-like receptors
- group A Streptococcus infections
- immature myeloid cells
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)