Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice

Takayuki Matsumura, Tadayoshi Ikebe, Koji Arikawa, Masahito Hosokawa, Michio Aiko, Aoi Iguchi, Ikuko Togashi, Sayaka Kai, Sakiko Ohara, Naoya Ohara, Makoto Ohnishi, Haruo Watanabe, Kazuo Kobayashi, Haruko Takeyama, Sho Yamasaki, Yoshimasa Takahashi, Manabu Ato

Research output: Contribution to journalArticle

Abstract

Matsumura et al. show that γIMCs sequentially sense group A Streptococcus (GAS) through TLR2 and Mincle. Specifically, TLR2-triggered production of IL-6 functions as an intermediate that amplifies Mincle expression to maximize host protection through IFN-γ production. The sequential sensing is a distinct feature in γIMCs following severe invasive GAS infection.

Original languageEnglish
Pages (from-to)561-571.e6
JournalCell Reports
Volume27
Issue number2
DOIs
Publication statusPublished - 2019 Apr 9

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Streptococcal Infections
Myeloid Cells
Streptococcus
Interleukin-6
Infection

Keywords

  • C-type lectin receptors
  • cytokines
  • group A Streptococcus infections
  • immature myeloid cells
  • Toll-like receptors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice. / Matsumura, Takayuki; Ikebe, Tadayoshi; Arikawa, Koji; Hosokawa, Masahito; Aiko, Michio; Iguchi, Aoi; Togashi, Ikuko; Kai, Sayaka; Ohara, Sakiko; Ohara, Naoya; Ohnishi, Makoto; Watanabe, Haruo; Kobayashi, Kazuo; Takeyama, Haruko; Yamasaki, Sho; Takahashi, Yoshimasa; Ato, Manabu.

In: Cell Reports, Vol. 27, No. 2, 09.04.2019, p. 561-571.e6.

Research output: Contribution to journalArticle

Matsumura, T, Ikebe, T, Arikawa, K, Hosokawa, M, Aiko, M, Iguchi, A, Togashi, I, Kai, S, Ohara, S, Ohara, N, Ohnishi, M, Watanabe, H, Kobayashi, K, Takeyama, H, Yamasaki, S, Takahashi, Y & Ato, M 2019, 'Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice', Cell Reports, vol. 27, no. 2, pp. 561-571.e6. https://doi.org/10.1016/j.celrep.2019.03.056
Matsumura, Takayuki ; Ikebe, Tadayoshi ; Arikawa, Koji ; Hosokawa, Masahito ; Aiko, Michio ; Iguchi, Aoi ; Togashi, Ikuko ; Kai, Sayaka ; Ohara, Sakiko ; Ohara, Naoya ; Ohnishi, Makoto ; Watanabe, Haruo ; Kobayashi, Kazuo ; Takeyama, Haruko ; Yamasaki, Sho ; Takahashi, Yoshimasa ; Ato, Manabu. / Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice. In: Cell Reports. 2019 ; Vol. 27, No. 2. pp. 561-571.e6.
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