Serial serum thrombopoietin levels in a pregnant woman with essential thrombocythaemia

Yosiiinobu Kanda, Sliigeru Cliiba, Yuji Tanaka, Akiyoshi Mlu'A, Alsushi Togawa, Takasiii Kato, Hiroshi Miyazaki, Ruriko Nisnino, Yosmo Yazaki, Hisamaru Hirai

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4 Citations (Scopus)

Abstract

Thrombopoietin (TPO) is a ligand for c-mpl, which regulates the differentiation and maturation of megakaryocytes. Essential thrombocythaemia (ET) is a clonal myeloproliferative disorder. It has been reported that the platelet count declines during pregnancy in ET patients. We examined serial changes in the serum TPO level during the course of pregnancy in a patient with ET. The serum TPO level showed significant negative correlation with the platelet count. Although it mimicked the normal feed back system, the TPO levels were consistently higher than the normal upper limit. Accumulation of these data will be helpful in revealing the pathogenesis of ET and the decline in the platelet count during pregnancy.

Original languageEnglish
Pages (from-to)271-273
Number of pages3
JournalBritish Journal of Haematology
Volume105
Issue number1
Publication statusPublished - 1999 May 6
Externally publishedYes

Keywords

  • Down-regulation
  • Essential thrombocythaemia
  • Feed- back
  • Pregnancy
  • Thrombopoietin

ASJC Scopus subject areas

  • Hematology

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    Kanda, Y., Cliiba, S., Tanaka, Y., Mlu'A, A., Togawa, A., Kato, T., Miyazaki, H., Nisnino, R., Yazaki, Y., & Hirai, H. (1999). Serial serum thrombopoietin levels in a pregnant woman with essential thrombocythaemia. British Journal of Haematology, 105(1), 271-273.