Serial serum thrombopoietin levels in a pregnant woman with essential thrombocythaemia

Yosiiinobu Kanda, Sliigeru Cliiba, Yuji Tanaka, Akiyoshi Mlu'A, Alsushi Togawa, Takashi Kato, Hiroshi Miyazaki, Ruriko Nisnino, Yosmo Yazaki, Hisamaru Hirai

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Thrombopoietin (TPO) is a ligand for c-mpl, which regulates the differentiation and maturation of megakaryocytes. Essential thrombocythaemia (ET) is a clonal myeloproliferative disorder. It has been reported that the platelet count declines during pregnancy in ET patients. We examined serial changes in the serum TPO level during the course of pregnancy in a patient with ET. The serum TPO level showed significant negative correlation with the platelet count. Although it mimicked the normal feed back system, the TPO levels were consistently higher than the normal upper limit. Accumulation of these data will be helpful in revealing the pathogenesis of ET and the decline in the platelet count during pregnancy.

Original languageEnglish
Pages (from-to)271-273
Number of pages3
JournalBritish Journal of Haematology
Volume105
Issue number1
Publication statusPublished - 1999
Externally publishedYes

Fingerprint

Thrombopoietin
Essential Thrombocythemia
Pregnant Women
Platelet Count
Serum
Pregnancy
Myeloproliferative Disorders
Megakaryocytes

Keywords

  • Down-regulation
  • Essential thrombocythaemia
  • Feed- back
  • Pregnancy
  • Thrombopoietin

ASJC Scopus subject areas

  • Hematology

Cite this

Kanda, Y., Cliiba, S., Tanaka, Y., Mlu'A, A., Togawa, A., Kato, T., ... Hirai, H. (1999). Serial serum thrombopoietin levels in a pregnant woman with essential thrombocythaemia. British Journal of Haematology, 105(1), 271-273.

Serial serum thrombopoietin levels in a pregnant woman with essential thrombocythaemia. / Kanda, Yosiiinobu; Cliiba, Sliigeru; Tanaka, Yuji; Mlu'A, Akiyoshi; Togawa, Alsushi; Kato, Takashi; Miyazaki, Hiroshi; Nisnino, Ruriko; Yazaki, Yosmo; Hirai, Hisamaru.

In: British Journal of Haematology, Vol. 105, No. 1, 1999, p. 271-273.

Research output: Contribution to journalArticle

Kanda, Y, Cliiba, S, Tanaka, Y, Mlu'A, A, Togawa, A, Kato, T, Miyazaki, H, Nisnino, R, Yazaki, Y & Hirai, H 1999, 'Serial serum thrombopoietin levels in a pregnant woman with essential thrombocythaemia', British Journal of Haematology, vol. 105, no. 1, pp. 271-273.
Kanda, Yosiiinobu ; Cliiba, Sliigeru ; Tanaka, Yuji ; Mlu'A, Akiyoshi ; Togawa, Alsushi ; Kato, Takashi ; Miyazaki, Hiroshi ; Nisnino, Ruriko ; Yazaki, Yosmo ; Hirai, Hisamaru. / Serial serum thrombopoietin levels in a pregnant woman with essential thrombocythaemia. In: British Journal of Haematology. 1999 ; Vol. 105, No. 1. pp. 271-273.
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