Serial 1H-MRS of thalamus during deep brain stimulation of bilateral globus pallidus internus for primary generalized dystonia

Mikhail F. Chernov, Taku Ochiai, Takaomi Taira, Yuko Ono, Ryoichi Nakamura, Yoshihiro Muragaki, Hiroshi Iseki, Tomokatsu Hori, Kintomo Takakura

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction: The physiological mechanisms of deep brain stimulation (DBS) are not completely clear. Our understanding of them may be facilitated with the use of proton magnetic resonance spectroscopy (1H-MRS). Methods: Serial 1H-MRS of both thalami was performed during the course of DBS of bilateral globus pallidus internus in a patient with primary generalized dystonia. Results: Two days after microelectrode implantation, a pulse frequency of 185 Hz was applied for stimulation. It resulted in relief of symptoms and a decrease of Burke-Fahn-Marsden dystonia rating scale (BFMDRS) scores, and was accompanied by a prominent increase of N-acetylaspartate (NAA)/choline- containing compounds (Cho) ratio, a mild increase of NAA/creatine (Cr) ratio, and a moderate decrease of Cho/Cr ratio. Two weeks later, for a search of the optimal stimulation mode, the pulse frequency was switched to 60 Hz, which resulted in clinical deterioration and significant increase of BFMDRS scores. At that time, all investigated 1H-MRS-detected metabolic parameters had nearly returned to the pretreatment levels. Conclusion: Use of serial 1H-MRS investigations of various brain structures during DBS in cases of movement disorders permits detailed evaluation of the treatment response, has a potential for its possible prediction, and may facilitate understanding of the physiological mechanisms of stimulation.

Original languageEnglish
Pages (from-to)1055-1059
Number of pages5
JournalNeuroradiology
Volume50
Issue number12
DOIs
Publication statusPublished - 2008 Dec
Externally publishedYes

Fingerprint

Dystonic Disorders
Globus Pallidus
Deep Brain Stimulation
Thalamus
Dystonia
Creatine
Movement Disorders
Microelectrodes
Choline
Proton Magnetic Resonance Spectroscopy
Brain

Keywords

  • Choline-containing compounds
  • Deep brain stimulation
  • Generalized dystonia
  • N-Acetylaspartate
  • Proton magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Chernov, M. F., Ochiai, T., Taira, T., Ono, Y., Nakamura, R., Muragaki, Y., ... Takakura, K. (2008). Serial 1H-MRS of thalamus during deep brain stimulation of bilateral globus pallidus internus for primary generalized dystonia. Neuroradiology, 50(12), 1055-1059. https://doi.org/10.1007/s00234-008-0458-7

Serial 1H-MRS of thalamus during deep brain stimulation of bilateral globus pallidus internus for primary generalized dystonia. / Chernov, Mikhail F.; Ochiai, Taku; Taira, Takaomi; Ono, Yuko; Nakamura, Ryoichi; Muragaki, Yoshihiro; Iseki, Hiroshi; Hori, Tomokatsu; Takakura, Kintomo.

In: Neuroradiology, Vol. 50, No. 12, 12.2008, p. 1055-1059.

Research output: Contribution to journalArticle

Chernov, MF, Ochiai, T, Taira, T, Ono, Y, Nakamura, R, Muragaki, Y, Iseki, H, Hori, T & Takakura, K 2008, 'Serial 1H-MRS of thalamus during deep brain stimulation of bilateral globus pallidus internus for primary generalized dystonia', Neuroradiology, vol. 50, no. 12, pp. 1055-1059. https://doi.org/10.1007/s00234-008-0458-7
Chernov, Mikhail F. ; Ochiai, Taku ; Taira, Takaomi ; Ono, Yuko ; Nakamura, Ryoichi ; Muragaki, Yoshihiro ; Iseki, Hiroshi ; Hori, Tomokatsu ; Takakura, Kintomo. / Serial 1H-MRS of thalamus during deep brain stimulation of bilateral globus pallidus internus for primary generalized dystonia. In: Neuroradiology. 2008 ; Vol. 50, No. 12. pp. 1055-1059.
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