Serotonin enhibits the induction of long-term potentiation in rat primary visual cortex

Yoshikuni Edagawa, Hikoshi Saito, Kazuho Abe

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Abstract

1. The effect of serotonin (5-hydroxytryptamine; 5-HT) on the induction of long-term potentiation (LTP) in rat visual cortex was investigated by using slice preparations in vitro. 2. Bath application of 5-HT (0.1-10 μM) did not affect the baseline synaptic potentials evoked by single-pulse test stimulation, but inhibited the induction of LTP in a concentration-dependent manner. 3. The effect of 5-HT was blocked by the 5-HTi receptor antagonist pindolol or the 5-HT2.7 receptor antagonist ritanserin, but not by the 5-HT3,4 receptor antagonist MDL72222. 4. These results suggest that 5-HT plays a role in suppressing the induction of LTP in the rat visual cortex.

Original languageEnglish
Pages (from-to)983-997
Number of pages15
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume22
Issue number6
Publication statusPublished - 1998 Aug 1

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Keywords

  • Cortex
  • Long-term potentiation
  • Primary visual
  • Serotonin

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

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