Serotonin transporter gene and inhibition of conflicting emotional information

Ai Koizumi, Norimichi Kitagawa, Miho Kitamura, Hirohito M. Kondo, Takao Sato, Makio Kashino

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Genetic variation of the serotonin-transporter-linked promoter region has been reported to be associated with susceptibility to mood disorders. However, little is known about the behavioral characteristics that mediate this genetic variation and susceptibility to depression. We examined whether the serotonin-transporter genotype modulates inhibition of facial expressions and emotional words in the emotional 'face-word' Stroop task. Although negative word distractors interfered with the valence identification of positive faces among carriers of two short alleles, positive word distractors interfered with that of negative faces among carriers of one or two long alleles. We discuss a possible role of the reduced inhibitory control over semantic negative information in carriers of two short alleles in the risk of developing depressive mental state.

Original languageEnglish
Pages (from-to)422-426
Number of pages5
JournalNeuroReport
Volume21
Issue number6
DOIs
Publication statusPublished - 2010
Externally publishedYes

Fingerprint

Serotonin Plasma Membrane Transport Proteins
Alleles
Genes
Facial Expression
Genetic Predisposition to Disease
Mood Disorders
Semantics
Genetic Promoter Regions
Genotype
Depression
Inhibition (Psychology)

Keywords

  • Depression
  • Emotion
  • Face-word Stroop
  • Inhibitory control
  • Interference effects
  • Polymorphisms of the serotonin transporter gene

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Serotonin transporter gene and inhibition of conflicting emotional information. / Koizumi, Ai; Kitagawa, Norimichi; Kitamura, Miho; Kondo, Hirohito M.; Sato, Takao; Kashino, Makio.

In: NeuroReport, Vol. 21, No. 6, 2010, p. 422-426.

Research output: Contribution to journalArticle

Koizumi, A, Kitagawa, N, Kitamura, M, Kondo, HM, Sato, T & Kashino, M 2010, 'Serotonin transporter gene and inhibition of conflicting emotional information', NeuroReport, vol. 21, no. 6, pp. 422-426. https://doi.org/10.1097/WNR.0b013e32833833f0
Koizumi, Ai ; Kitagawa, Norimichi ; Kitamura, Miho ; Kondo, Hirohito M. ; Sato, Takao ; Kashino, Makio. / Serotonin transporter gene and inhibition of conflicting emotional information. In: NeuroReport. 2010 ; Vol. 21, No. 6. pp. 422-426.
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