Serum thrombopoietin level in various hematological diseases

Kensuke Usuki, Tomoyuki Tahara, Seiko Iki, Mitsue Endo, Mayumi Osawa, Koichi Kitazume, Takashi Kato, Hiroshi Miyazaki, Akio Urabe

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Abstract

To investigate the pathophysiological role of thrombopoietin (TPO) in thrombopoiesis, we measured its serum levels in 15 healthy individuals, 84 patients with various hematological diseases and 2 patients with liver cirrhosis using an enzyme immunoassay procedure. The TPO level was 0.84 ± 0.40 f mol/ml in normal individuals. TPO levels were considerably elevated in patients with myelosuppression after intensification chemotherapy of acute leukemia in complete remission (postchemotherapy group: n = 18; 18.46 ± 9.70) f mol/ml). When the data of normal individuals and the postchemotherapy group were combined, TPO levels were inversely correlated with the platelet count in this combined group. We compared these data of normal individuals and the postchemotherapy group with various hematological disease states. In aplastic anemia (n = 13; 16.03 ± 9.44 f mol/ml, acute lymphoblastic leukemia (n = 5; 10.36 ± 5.57 f mol/ml), malignant lymphoma (n = 6; 2.79 ± 2.27 f mol/ml), multiple myeloma (n = 3; 3.34 ± 0.20 f mol/ml and chronic lymphocytic leukemia (n = 21 1.71 ± 3.91 f mol/ml), the relationship of serum TPO levels and platelet counts was almost the same as in the combined group with normal individuals and the postchemotherapy group. However, the TPO levels were slightly higher in myeloproliferative disorders (n = 12; 1.99 ± 1.47 f mol/ml) and lower in acute myelogenous leukemia (n = 8; 2.27 ± 1.25 f mol/ml), hypoplastic leukemia (n = 3; 2.76 ± 2.23 f mol/ml, myelodysplastic syndrome (n = 2; 0.42 ± 0.60 f mol/ml), liver cirrhosis (n = 2; 1.50 ± 0.92 f mol/ml) and idiopathic thrombocytopenicpurpura (n = 12; 2.08 ± 1.41 f mol/ml), when compared to the regression line for the combined group with normal individuals and postchemotherapy group. These findings suggest that TPO might play an important role in regulation of the platelet count in normal and pathological conditions.

Original languageEnglish
Pages (from-to)558-565
Number of pages8
JournalSTEM CELLS
Volume14
Issue number5
DOIs
Publication statusPublished - 1996 Sep

Keywords

  • Aplastic anemia
  • Idiopathic thrombocytopenic purpura
  • Leukemia
  • Liver cirrhosis
  • Malignant lymphoma
  • Multiple myeloma
  • Myelodysplastic syndrome
  • Myeloproliferative disorders
  • Myelosuppressive state
  • Serum level
  • Thrombopoietin

ASJC Scopus subject areas

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology

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  • Cite this

    Usuki, K., Tahara, T., Iki, S., Endo, M., Osawa, M., Kitazume, K., Kato, T., Miyazaki, H., & Urabe, A. (1996). Serum thrombopoietin level in various hematological diseases. STEM CELLS, 14(5), 558-565. https://doi.org/10.1002/stem.140558