Serum thrombopoietin (TPO) levels in patients with amegakaryocytic thrombocytopenia are much higher than those with immune thrombocytopenic purpura

Harumi Y. Mukai, Hiroshi Kojima, Kazuo Todokoro, Tomoyuki Tahara, Takashi Kato, Yuichi Hasegawa, Toshitaka Kobayashi, Haruhiko Ninomiya, Toshiro Nagasawa, Tsukasa Abe

Research output: Contribution to journalArticle

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Abstract

We assayed serum thrombopoietin (TPO) levels in amegakaryocytic thrombocytopenia (AMT) and immune thrombocytopenic purpura (ITP) patients by using a newly established enzyme-linked immunosorbent assay (ELISA). TPO levels in AMT patients were quite high (mean ± SD = 13.7 ± 11.2 fmoles/ml, n = 4), whereas those in ITP patients were only slightly higher (1.25 ± 0.39, n = 12) than those of the healthy donors (0.55 ± 0.2, n = 20). Furthermore, in ITP patients no correlation was observed between platelet counts and serum TPO levels (correlation coefficient = 0.14). We further assayed serum TPO levels sequentially during steroid treatment in patients with AMT and ITP. In one AMT patient serum TPO levels started to decrease in accordance with the increase of megakaryocyte counts, which preceded the increase in platelet counts. However, in ITP patients serum TPO levels did not change significantly throughout the course of the treatment despite the recovery of platelet counts. Based on these findings, we conclude that serum TPO levels may be regulated at least in part by megakaryocyte counts.

Original languageEnglish
Pages (from-to)675-678
Number of pages4
JournalThrombosis and Haemostasis
Volume76
Issue number5
DOIs
Publication statusPublished - 1996 Nov

ASJC Scopus subject areas

  • Hematology

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