Sex differences in the photoperiodic regulation of RF-Amide related peptide (RFRP) and its receptor GPR147 in the syrian hamster

Jo B. Henningsen, Vincent Joseph Poirel, Jens D. Mikkelsen, Kazuyoshi Tsutsui, Valérie Simonneaux, François Gauer

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    RF-(Arg-Phe) related peptides (RFRP-1 and -3) are considered to play a role in the seasonal regulation of reproduction; however, the effect of the peptides depends on species and gender. This study aimed at comparing the RFRP system in male and female Syrian hamsters over long and short photoperiods to investigate the neuroanatomical basis of these differential effects. The neuroanatomical distribution of RFRP neurons and fibers, revealed using an antiserum recognizing RFRP-1 and -3, as well as GPR147 mRNA, are similar in male and female Syrian hamsters. RFRP neurons are mainly found in the medial hypothalamus, whereas RFRP projections and GPR147 mRNA are observed in the preoptic area, anteroventral-periventricular nucleus, suprachiasmatic nucleus, paraventricular nucleus, bed nucleus of the stria terminalis, ventromedial hypothalamus, habenular nucleus, and arcuate nucleus. The number of RFRP neurons is higher in females than in males, and in both sexes, the number of RFRP neurons is reduced in short photoperiods. GPR147 mRNA levels are higher in females than in males and are downregulated in short photoperiods, particularly in females. Interestingly, the number of RFRP-positive fibers in the anteroventral-periventricular nucleus is higher only in females adjusted to a short photoperiod. Our results suggest that the RFRP system, which is strongly regulated by photoperiod in both male and female Syrian hamsters, is particularly important in females, with a distinct role in the anteroventral-periventricular nucleus, possibly in the regulation of the preovulatory luteinizing hormone surge via kisspeptin neurons. J. Comp. Neurol. 524:1825-1838, 2016.

    Original languageEnglish
    Pages (from-to)1825-1838
    Number of pages14
    JournalJournal of Comparative Neurology
    Volume524
    Issue number9
    DOIs
    Publication statusPublished - 2016 Jun 15

    Fingerprint

    Peptide Receptors
    Mesocricetus
    Amides
    Sex Characteristics
    Peptides
    Photoperiod
    Anterior Hypothalamus
    Neurons
    Messenger RNA
    Kisspeptins
    Habenula
    Middle Hypothalamus
    Septal Nuclei
    Arcuate Nucleus of Hypothalamus
    Suprachiasmatic Nucleus
    Preoptic Area
    Paraventricular Hypothalamic Nucleus
    Luteinizing Hormone
    Hypothalamus
    Reproduction

    Keywords

    • Dorso/ventromedial hypothalamus
    • GnRH
    • Seasonal reproduction

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Sex differences in the photoperiodic regulation of RF-Amide related peptide (RFRP) and its receptor GPR147 in the syrian hamster. / Henningsen, Jo B.; Poirel, Vincent Joseph; Mikkelsen, Jens D.; Tsutsui, Kazuyoshi; Simonneaux, Valérie; Gauer, François.

    In: Journal of Comparative Neurology, Vol. 524, No. 9, 15.06.2016, p. 1825-1838.

    Research output: Contribution to journalArticle

    Henningsen, Jo B. ; Poirel, Vincent Joseph ; Mikkelsen, Jens D. ; Tsutsui, Kazuyoshi ; Simonneaux, Valérie ; Gauer, François. / Sex differences in the photoperiodic regulation of RF-Amide related peptide (RFRP) and its receptor GPR147 in the syrian hamster. In: Journal of Comparative Neurology. 2016 ; Vol. 524, No. 9. pp. 1825-1838.
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    AU - Poirel, Vincent Joseph

    AU - Mikkelsen, Jens D.

    AU - Tsutsui, Kazuyoshi

    AU - Simonneaux, Valérie

    AU - Gauer, François

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