Sex Differences in the Relationship Between Estrogen Receptor Alpha Gene Polymorphisms and Arterial Stiffness in Older Humans

Koichiro Hayashi, Seiji Maeda, Motoyuki Iemitsu, Takeshi Otsuki, Jun Sugawara, Takumi Tanabe, Takashi Miyauchi, Shinya Kuno, Ryuichi Ajisaka, Mitsuo Matsuda

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Background: Increased arterial stiffness is an independent risk factor for cardiovascular disease. The estrogen system (estrogen and estrogen receptor-α [ER-α]) has potent vasodilator and antiatherosclerotic activity in vascular tissue and therefore was implicated in the regulation of arterial stiffness. We hypothesized that the relationship between arterial stiffness and gene polymorphisms in ER-α has a sex-specific component in older humans. Methods: Two hundred healthy older subjects, comprised of 85 men and 115 postmenopausal women (men, 66 ± 5 years old; women, 64 ± 7 years old; mean ± SD) participated in a cross-sectional study. We determined the genotypes of single-nucleotide polymorphisms (SNPs) at -401T/C of intron 1 and at 30T/C of exon 1 of ER-α, using a TaqMan-polymerase chain reaction method. Arterial stiffness was estimated by brachial-ankle pulse-wave velocity (baPWV). Results: Polymorphisms of both -401T/C and 30T/C in ER-α affected baPWV values in postmenopausal women but did not affect men. The baPWV in women was significantly lower in the CC genotype at both -401T/C and 30T/C than in the TT genotype (both P < .05), and the CC genotype of two SNPs in women was significantly lower than in men. Conclusions: The present study suggests that the relationship between arterial stiffness and -401T/C or 30T/C polymorphisms in ER-α is different between sexes in older humans. These polymorphisms may be important in the health and clinical care of cardiovascular function and disease in older women.

Original languageEnglish
Pages (from-to)650-656
Number of pages7
JournalAmerican Journal of Hypertension
Volume20
Issue number6
DOIs
Publication statusPublished - 2007 Jun
Externally publishedYes

Keywords

  • estrogen receptor alpha
  • pulse-wave velocity
  • Sex difference
  • single-nucleotide polymorphism

ASJC Scopus subject areas

  • Internal Medicine

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