Sexual function is an indicator of central arterial stiffness and arterial stiffness gradient in Japanese adult men

Hiroshi Kumagai, Toru Yoshikawa, Kanae Myoenzono, Keisei Kosaki, Nobuhiko Akazawa, Zempo Miyaki Asako, Takehiko Tsujimoto, Tetsuhiro Kidokoro, Kiyoji Tanaka, Seiji Maeda

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Background--As arterial stiffness increases in the absence of subjective symptoms, a personal indicator that reflects increased risk of cardiovascular disease is necessary. Penile erection is regulated by vascular function, and atherosclerosis affects the penile artery earlier than it affects the coronary and carotid arteries. Therefore, we hypothesized that deterioration of erectile function could be a marker of increased risk for cardiovascular disease. To test our hypothesis, we assessed erectile function and arterial stiffness in a cross-sectional study. Methods and Results--Carotid-femoral pulse wave velocity (PWV), brachial-ankle PWV, femoral-ankle PWV, and arterial stiffness gradient (PWV ratio: carotid-femoral PWV/femoral-ankle PWV) were measured as indexes of central, systemic, and peripheral arterial stiffness and peripheral organ damage, respectively, in 317 adult men. In addition, erectile function was assessed by using the questionnaire International Index of Erectile Function 5 (a descending score indicates worsening of erectile function). The scores of male sexual function were inversely correlated with carotid-femoral PWV (rs=-0.41), brachial-ankle PWV (rs=-0.35), femoral-ankle PWV (rs=-0.19), and PWV ratio (rs=-0.33). Furthermore, multivariate linear regression analyses revealed that International Index of Erectile Function 5 scores were significantly associated with carotid-femoral PWV (β=-0.22) and PWV ratio (β=-0.25), but not with brachial-ankle PWV and femoral-ankle PWV. Conclusions--Our results indicated that erectile function is independently associated with central arterial stiffness and peripheral organ damage. These findings suggest that male sexual function could be an easily identifiable and independent marker of increased central arterial stiffness and peripheral organ damage.

Original languageEnglish
Article numbere007964
JournalJournal of the American Heart Association
Volume7
Issue number10
DOIs
Publication statusPublished - 2018 May 15
Externally publishedYes

Keywords

  • Arterial stiffness
  • Erectile dysfunction
  • Predictors
  • Sexual dysfunction
  • Vascular function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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