Shape Change and Growth Behavior of Monosodium Urate Monohydrate in a Gout Model

Chihiro Ozono; Izumi Hirasawa; Fukashi Kohori

doi:10.1002/ceat.201600680

Shape Change and Growth Behavior of Monosodium Urate Monohydrate in a Gout Model

Chihiro Ozono, Izumi Hirasawa, Fukashi Kohori^*

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Deposition of needle-shaped monosodium urate monohydrate (MSU) crystals in synovial fluid provokes the acute inflammatory response of gout. The mechanism of MSU crystallization was investigated in batch operation under the same pH and Na⁺ concentration of synovial fluid. It was found that stirring enhanced the aggregation of needle-shaped MSU, and the deposition of MSU was faster and larger in amount. MSU crystals in supersaturated urate solution were detected by dynamic light scattering and UV absorption, suggesting that the urate concentration affected not the crystal growth but nucleation. Since the increase of the number of MSU crystals is assumed to cause a high risk of gout, this result supports the importance of the control of serum urate level as a treatment of gout.

Original language	English
Pages (from-to)	1231-1234
Number of pages	4
Journal	Chemical Engineering and Technology
Volume	40
Issue number	7
DOIs	https://doi.org/10.1002/ceat.201600680
Publication status	Published - 2017 Jul

Keywords

Crystal shape
Crystallization
Gout
Monosodium urate monohydrate
Nucleation

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)
Industrial and Manufacturing Engineering

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title = "Shape Change and Growth Behavior of Monosodium Urate Monohydrate in a Gout Model",

abstract = "Deposition of needle-shaped monosodium urate monohydrate (MSU) crystals in synovial fluid provokes the acute inflammatory response of gout. The mechanism of MSU crystallization was investigated in batch operation under the same pH and Na+ concentration of synovial fluid. It was found that stirring enhanced the aggregation of needle-shaped MSU, and the deposition of MSU was faster and larger in amount. MSU crystals in supersaturated urate solution were detected by dynamic light scattering and UV absorption, suggesting that the urate concentration affected not the crystal growth but nucleation. Since the increase of the number of MSU crystals is assumed to cause a high risk of gout, this result supports the importance of the control of serum urate level as a treatment of gout.",

keywords = "Crystal shape, Crystallization, Gout, Monosodium urate monohydrate, Nucleation",

author = "Chihiro Ozono and Izumi Hirasawa and Fukashi Kohori",

note = "Funding Information: This work was supported by JSPS KAKENHI, Grant No. JP16K14464. The authors have declared no conflict of interest. Publisher Copyright: {\textcopyright} 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2017",

month = jul,

doi = "10.1002/ceat.201600680",

language = "English",

volume = "40",

pages = "1231--1234",

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T1 - Shape Change and Growth Behavior of Monosodium Urate Monohydrate in a Gout Model

AU - Ozono, Chihiro

AU - Hirasawa, Izumi

AU - Kohori, Fukashi

N1 - Funding Information: This work was supported by JSPS KAKENHI, Grant No. JP16K14464. The authors have declared no conflict of interest. Publisher Copyright: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2017/7

Y1 - 2017/7

N2 - Deposition of needle-shaped monosodium urate monohydrate (MSU) crystals in synovial fluid provokes the acute inflammatory response of gout. The mechanism of MSU crystallization was investigated in batch operation under the same pH and Na+ concentration of synovial fluid. It was found that stirring enhanced the aggregation of needle-shaped MSU, and the deposition of MSU was faster and larger in amount. MSU crystals in supersaturated urate solution were detected by dynamic light scattering and UV absorption, suggesting that the urate concentration affected not the crystal growth but nucleation. Since the increase of the number of MSU crystals is assumed to cause a high risk of gout, this result supports the importance of the control of serum urate level as a treatment of gout.

AB - Deposition of needle-shaped monosodium urate monohydrate (MSU) crystals in synovial fluid provokes the acute inflammatory response of gout. The mechanism of MSU crystallization was investigated in batch operation under the same pH and Na+ concentration of synovial fluid. It was found that stirring enhanced the aggregation of needle-shaped MSU, and the deposition of MSU was faster and larger in amount. MSU crystals in supersaturated urate solution were detected by dynamic light scattering and UV absorption, suggesting that the urate concentration affected not the crystal growth but nucleation. Since the increase of the number of MSU crystals is assumed to cause a high risk of gout, this result supports the importance of the control of serum urate level as a treatment of gout.

KW - Crystal shape

KW - Crystallization

KW - Gout

KW - Monosodium urate monohydrate

KW - Nucleation

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JO - Chemical Engineering and Technology

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IS - 7

ER -

Shape Change and Growth Behavior of Monosodium Urate Monohydrate in a Gout Model

Abstract

Keywords

ASJC Scopus subject areas

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