Shape Change and Growth Behavior of Monosodium Urate Monohydrate in a Gout Model

    Research output: Contribution to journalArticle

    Abstract

    Deposition of needle-shaped monosodium urate monohydrate (MSU) crystals in synovial fluid provokes the acute inflammatory response of gout. The mechanism of MSU crystallization was investigated in batch operation under the same pH and Na+ concentration of synovial fluid. It was found that stirring enhanced the aggregation of needle-shaped MSU, and the deposition of MSU was faster and larger in amount. MSU crystals in supersaturated urate solution were detected by dynamic light scattering and UV absorption, suggesting that the urate concentration affected not the crystal growth but nucleation. Since the increase of the number of MSU crystals is assumed to cause a high risk of gout, this result supports the importance of the control of serum urate level as a treatment of gout.

    Original languageEnglish
    Pages (from-to)1231-1234
    Number of pages4
    JournalChemical Engineering and Technology
    Volume40
    Issue number7
    DOIs
    Publication statusPublished - 2017 Jul 1

    Fingerprint

    Uric Acid
    Needles
    Crystals
    Fluids
    Dynamic light scattering
    Crystal growth
    Nucleation
    Agglomeration
    Crystallization

    Keywords

    • Crystal shape
    • Crystallization
    • Gout
    • Monosodium urate monohydrate
    • Nucleation

    ASJC Scopus subject areas

    • Chemistry(all)
    • Chemical Engineering(all)
    • Industrial and Manufacturing Engineering

    Cite this

    Shape Change and Growth Behavior of Monosodium Urate Monohydrate in a Gout Model. / Ozono, Chihiro; Hirasawa, Izumi; Kohori, Fukashi.

    In: Chemical Engineering and Technology, Vol. 40, No. 7, 01.07.2017, p. 1231-1234.

    Research output: Contribution to journalArticle

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