Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata

Shuhei Murayama, Yasufumi Imae, Kentaro Takada, Jo Kikuchi, Yoichi Nakao, Rob W.M. Van Soest, Shigeru Okada, Shigeki Matsunaga*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Two dimeric steroid derivatives, shishicrellastatin A (1) and B (2), have been isolated as cathepsin B inhibitors from the marine sponge Crella (Yvesia) spinulata. Their structures were determined by interpretation of spectroscopic data. Shishicrellastatins inhibit cathepsin B with an IC 50 value of 8 μg/mL each.

Original languageEnglish
Pages (from-to)6594-6598
Number of pages5
JournalBioorganic and Medicinal Chemistry
Volume19
Issue number22
DOIs
Publication statusPublished - 2011 Nov 15
Externally publishedYes

Keywords

  • Cathepsin B
  • Crellastatin
  • Dimeric
  • Sponge
  • Steroid
  • Structure elucidation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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