Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata

Shuhei Murayama, Yasufumi Imae, Kentaro Takada, Jo Kikuchi, Yoichi Nakao, Rob W.M. Van Soest, Shigeru Okada, Shigeki Matsunaga

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Two dimeric steroid derivatives, shishicrellastatin A (1) and B (2), have been isolated as cathepsin B inhibitors from the marine sponge Crella (Yvesia) spinulata. Their structures were determined by interpretation of spectroscopic data. Shishicrellastatins inhibit cathepsin B with an IC 50 value of 8 μg/mL each.

Original languageEnglish
Pages (from-to)6594-6598
Number of pages5
JournalBioorganic and Medicinal Chemistry
Volume19
Issue number22
DOIs
Publication statusPublished - 2011 Nov 15
Externally publishedYes

Keywords

  • Cathepsin B
  • Crellastatin
  • Dimeric
  • Sponge
  • Steroid
  • Structure elucidation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata'. Together they form a unique fingerprint.

  • Cite this

    Murayama, S., Imae, Y., Takada, K., Kikuchi, J., Nakao, Y., Van Soest, R. W. M., Okada, S., & Matsunaga, S. (2011). Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata. Bioorganic and Medicinal Chemistry, 19(22), 6594-6598. https://doi.org/10.1016/j.bmc.2011.06.052