Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata

Shuhei Murayama, Yasufumi Imae, Kentaro Takada, Jo Kikuchi, Yoichi Nakao, Rob W.M. Van Soest, Shigeru Okada, Shigeki Matsunaga

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Two dimeric steroid derivatives, shishicrellastatin A (1) and B (2), have been isolated as cathepsin B inhibitors from the marine sponge Crella (Yvesia) spinulata. Their structures were determined by interpretation of spectroscopic data. Shishicrellastatins inhibit cathepsin B with an IC 50 value of 8 μg/mL each.

Original languageEnglish
Pages (from-to)6594-6598
Number of pages5
JournalBioorganic and Medicinal Chemistry
Issue number22
Publication statusPublished - 2011 Nov 15
Externally publishedYes


  • Cathepsin B
  • Crellastatin
  • Dimeric
  • Sponge
  • Steroid
  • Structure elucidation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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