Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata

Shuhei Murayama, Yasufumi Imae, Kentaro Takada, Jo Kikuchi, Youichi Nakao, Rob W M Van Soest, Shigeru Okada, Shigeki Matsunaga

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Two dimeric steroid derivatives, shishicrellastatin A (1) and B (2), have been isolated as cathepsin B inhibitors from the marine sponge Crella (Yvesia) spinulata. Their structures were determined by interpretation of spectroscopic data. Shishicrellastatins inhibit cathepsin B with an IC 50 value of 8 μg/mL each.

Original languageEnglish
Pages (from-to)6594-6598
Number of pages5
JournalBioorganic and Medicinal Chemistry
Volume19
Issue number22
DOIs
Publication statusPublished - 2011 Nov 15
Externally publishedYes

Fingerprint

Cathepsin B
Porifera
Steroids
Derivatives

Keywords

  • Cathepsin B
  • Crellastatin
  • Dimeric
  • Sponge
  • Steroid
  • Structure elucidation

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata. / Murayama, Shuhei; Imae, Yasufumi; Takada, Kentaro; Kikuchi, Jo; Nakao, Youichi; Van Soest, Rob W M; Okada, Shigeru; Matsunaga, Shigeki.

In: Bioorganic and Medicinal Chemistry, Vol. 19, No. 22, 15.11.2011, p. 6594-6598.

Research output: Contribution to journalArticle

Murayama, S, Imae, Y, Takada, K, Kikuchi, J, Nakao, Y, Van Soest, RWM, Okada, S & Matsunaga, S 2011, 'Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata', Bioorganic and Medicinal Chemistry, vol. 19, no. 22, pp. 6594-6598. https://doi.org/10.1016/j.bmc.2011.06.052
Murayama, Shuhei ; Imae, Yasufumi ; Takada, Kentaro ; Kikuchi, Jo ; Nakao, Youichi ; Van Soest, Rob W M ; Okada, Shigeru ; Matsunaga, Shigeki. / Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata. In: Bioorganic and Medicinal Chemistry. 2011 ; Vol. 19, No. 22. pp. 6594-6598.
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