Short-term potentiation at the parallel fiber-Purkinje cell synapse

Jun Ichi Goto, Takafumi Inoue, Akinori Kuruma, Katsuhiko Mikoshiba

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Changes in synaptic efficacy at the parallel fiber (PF)-Purkinje cell (PC) synapse are postulated to be a cellular basis for motor learning. Although long-term efficacy changes lasting more than an hour at this synapse, i.e., long-term potentiation and depression, have been extensively studied, relatively short lasting synaptic efficacy changes, namely short-term potentiation (STP) lasting for tens of minutes, have not been discussed to date. Here we report that this synapse shows an apparent STP reliably by a periodic burst pattern of homosynaptic stimulation. This STP is presynaptically expressed, since it accompanies with a reduced paired-pulse facilitation and is resistant to postsynaptic Ca2+ reduction by BAPTA injection or in P/Q-type Ca channel knockout cerebella. This novel type of synaptic plasticity at the PF-PC synapse would be a clue for understanding the presynaptic mechanisms of plasticity at this synapse.

Original languageEnglish
Pages (from-to)28-33
Number of pages6
JournalNeuroscience Research
Volume55
Issue number1
DOIs
Publication statusPublished - 2006 May
Externally publishedYes

Fingerprint

Purkinje Cells
Synapses
Neuronal Plasticity
Long-Term Potentiation
Cerebellum
Learning
Depression
Injections

Keywords

  • Brain slice
  • Cerebellum
  • Electrophysiology
  • Parallel fiber
  • Purkinje cell
  • Short-term potentiation
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Short-term potentiation at the parallel fiber-Purkinje cell synapse. / Goto, Jun Ichi; Inoue, Takafumi; Kuruma, Akinori; Mikoshiba, Katsuhiko.

In: Neuroscience Research, Vol. 55, No. 1, 05.2006, p. 28-33.

Research output: Contribution to journalArticle

Goto, Jun Ichi ; Inoue, Takafumi ; Kuruma, Akinori ; Mikoshiba, Katsuhiko. / Short-term potentiation at the parallel fiber-Purkinje cell synapse. In: Neuroscience Research. 2006 ; Vol. 55, No. 1. pp. 28-33.
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