@article{635dfc72fae1434c889699dd601393d9,
title = "Si-doping increases the adjuvant activity of hydroxyapatite nanorods",
abstract = " Recombinant protein-based vaccines generally show limited immunogenicity and need adjuvants to achieve robust immune responses. Herein, to combine the excellent biocompatibility of hydroxyapatite (HA) and exciting adjuvant activity of silica, Si-doped HA nanorods with Si/P molar ratio from 0 to 0.65 were hydrothermally synthesized and evaluated as immunoadjuvants. Si-doping decreases the size and increases the BET surface area of the nanorods. Si-doping in HA nanorods increases the in vitro adjuvant activity, including CD11c + CD86 + expression and cytokine secretion of bone marrow derived dendritic cells (BMDCs). Moreover, Si-doping in HA increases the ex vivo adjuvant activity as shown by the increase in both Th1 and Th2 cytokines secretion. Si-doped HA nanorods are promising as a new immunoadjuvant. ",
keywords = "Adjuvant, Cytokine secretion, Hydroxyapatite, Si-doping, Th1, Th2",
author = "Xiupeng Wang and Shu Ihara and Xia Li and Atsuo Ito and Yu Sogo and Yohei Watanabe and Tsuji, {Noriko M.} and Atsushi Yamazaki",
note = "Funding Information: We thank Prof. Tadao Ohno at The Nippon Dental University and Prof. Koji Tsuboi at University of Tsukuba for fruitful discussion. This study was supported in part by JSPS KAKENHI Grant Numbers 17K01399 and 26750162 , NIMS microstructural characterization platform and NIMS Molecule & Material Synthesis Platform in “Nanotechnology Platform Project” operated by the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan. NMT thanks Japan Society for the Promotion Science 15H04504 (JSPS), a Grant-in-Aid from Strategic International Collaborative Research Program (SICORP) , a Grant-in-Aid from Cross-ministerial Strategic Innovation Promotion Program (SIP) , the Research Program on Hepatitis from Japan Agency for Medical Research and Development 17fk0210305h0003 (AMED), and a Grant-in-Aid from the Canon Foundation . Funding Information: We thank Prof. Tadao Ohno at The Nippon Dental University and Prof. Koji Tsuboi at University of Tsukuba for fruitful discussion. This study was supported in part by JSPS KAKENHI Grant Numbers 17K01399 and 26750162, NIMS microstructural characterization platform and NIMS Molecule & Material Synthesis Platform in “Nanotechnology Platform Project” operated by the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan. NMT thanks Japan Society for the Promotion Science 15H04504 (JSPS), a Grant-in-Aid from Strategic International Collaborative Research Program (SICORP), a Grant-in-Aid from Cross-ministerial Strategic Innovation Promotion Program (SIP), the Research Program on Hepatitis from Japan Agency for Medical Research and Development17fk0210305h0003 (AMED), and a Grant-in-Aid from the Canon Foundation. Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",
year = "2019",
month = feb,
day = "1",
doi = "10.1016/j.colsurfb.2018.11.026",
language = "English",
volume = "174",
pages = "300--307",
journal = "Colloids and Surfaces B: Biointerfaces",
issn = "0927-7765",
publisher = "Elsevier",
}