Sialylglycan-modified field effect transistor for detection of charged lectin under physiological conditions

Takahiro Nakamura, Yoshihiro Sakurai, Sho Hideshima, Shigeki Kuroiwa, Tetsuya Osaka

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Determination of protein charges under physiological conditions by field effect transistors (FETs) is challenging because of the screening effect by solution counter ions. We showed that sugar-chain-modified FETs can detect proteins under physiological conditions. Protein charges are detectable on the gate interface by applying sugar chains as receptors: these sugar chains are short and highly flexible. Threshold voltage shifts caused by adsorption of SSA lectin from Sambucus sieboldiana onto sialylglycan-modified FET showed a linear relationship with SSA concentrations under physiological conditions.

Original languageEnglish
Pages (from-to)1245-1247
Number of pages3
JournalChemistry Letters
Volume39
Issue number12
DOIs
Publication statusPublished - 2010 Dec 13

    Fingerprint

ASJC Scopus subject areas

  • Chemistry(all)

Cite this