Signal transduction cascades underlying de novo protein synthesis required for neuronal morphogenesis in differentiating neurons

Takuro Tojima, Etsuro Ito

Research output: Contribution to journalReview article

49 Citations (Scopus)

Abstract

Differentiating neurons must acquire many unique morphological and functional characteristics in creating the precise neural circuits of the mature nervous system. The phenomenon of 'neuronal differentiation' includes a special set of simple, separate processes, that is, neuritogenesis, neurite outgrowth, pathfinding, targeting and synaptogenesis. All of these processes are critically dependent on the reorganization of actin cytoskeleton by many actin-binding proteins that function downstream of Rho-family GTPases. Furthermore, de novo synthesis of key proteins are critically involved in the reorganization of actin cytoskeleton during neuronal differentiation. In this article, we review recent progresses in the general mechanisms that control actin dynamics by various actin-binding proteins in differentiating neurons, including a series of recent studies from our laboratory on de novo synthesis of several key proteins that are essential for actin reorganization induced by second messengers. We demonstrated that dual regulation of cyclic AMP and Ca2+ determines cofilin (an actin-binding protein) phosphorylation states and LIM kinase 1 (a cofilin kinase) expression level during neuritogenesis.

Original languageEnglish
Pages (from-to)183-193
Number of pages11
JournalProgress in Neurobiology
Volume72
Issue number3
DOIs
Publication statusPublished - 2004 Feb
Externally publishedYes

Fingerprint

Microfilament Proteins
Morphogenesis
Signal Transduction
Actin Cytoskeleton
Neurons
Actins
Cofilin 1
Lim Kinases
Actin Depolymerizing Factors
rho GTP-Binding Proteins
Proteins
Second Messenger Systems
Cyclic AMP
Nervous System
Phosphotransferases
Phosphorylation

Keywords

  • AC
  • acetylcholine
  • acetylcholinesterase
  • ACh
  • AChE
  • actin depolymerizing factor
  • actin-related protein 2/3
  • adenylyl cyclase
  • ADF
  • AFM
  • Arp2/3
  • atomic force microscopy
  • CAM
  • CaM kinase II
  • cAMP
  • cell adhesion molecule
  • cyclic AMP

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Signal transduction cascades underlying de novo protein synthesis required for neuronal morphogenesis in differentiating neurons. / Tojima, Takuro; Ito, Etsuro.

In: Progress in Neurobiology, Vol. 72, No. 3, 02.2004, p. 183-193.

Research output: Contribution to journalReview article

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