Significance of plasma endothelin-1 levels in patients with systemic sclerosis

K. Yamane, T. Miyauchi, N. Suzuki, T. Yuhara, Takao Akama, H. Suzuki, H. Kashiwagi

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

Endothelin-1 (ET-1) is a novel potent vasoconstrictor peptide discovered in the supernatant fraction of cultured endothelial cells. We measured plasma levels of ET-1 using a sensitive sandwich enzyme immunoassay. Plasma concentrations of ET-1 in 31 patients with systemic sclerosis (SSc) (1.90 + 0.47 pg/ml) were higher than those (1.31 + 0.10 pg/ml) in 25 age and sex matched healthy subjects. Patients with SSc with diffuse scleroderma had higher levels of ET-1 compared with those with limited scleroderma. Plasma ET-1 levels correlated inversely with carbon monoxide diffusing capacity (DL(co)). Measurement of plasma ET-1 levels may be useful as a predictor of prognosis of SSc.

Original languageEnglish
Pages (from-to)1566-1571
Number of pages6
JournalJournal of Rheumatology
Volume19
Issue number10
Publication statusPublished - 1992
Externally publishedYes

Fingerprint

Systemic Scleroderma
Endothelin-1
Limited Scleroderma
Diffuse Scleroderma
Vasoconstrictor Agents
Carbon Monoxide
Immunoenzyme Techniques
Cultured Cells
Healthy Volunteers
Endothelial Cells
Peptides

Keywords

  • carbon monoxide diffusing capacity
  • endothelin-1
  • Raynaud's phenomenon
  • systemic sclerosis

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Yamane, K., Miyauchi, T., Suzuki, N., Yuhara, T., Akama, T., Suzuki, H., & Kashiwagi, H. (1992). Significance of plasma endothelin-1 levels in patients with systemic sclerosis. Journal of Rheumatology, 19(10), 1566-1571.

Significance of plasma endothelin-1 levels in patients with systemic sclerosis. / Yamane, K.; Miyauchi, T.; Suzuki, N.; Yuhara, T.; Akama, Takao; Suzuki, H.; Kashiwagi, H.

In: Journal of Rheumatology, Vol. 19, No. 10, 1992, p. 1566-1571.

Research output: Contribution to journalArticle

Yamane, K, Miyauchi, T, Suzuki, N, Yuhara, T, Akama, T, Suzuki, H & Kashiwagi, H 1992, 'Significance of plasma endothelin-1 levels in patients with systemic sclerosis', Journal of Rheumatology, vol. 19, no. 10, pp. 1566-1571.
Yamane K, Miyauchi T, Suzuki N, Yuhara T, Akama T, Suzuki H et al. Significance of plasma endothelin-1 levels in patients with systemic sclerosis. Journal of Rheumatology. 1992;19(10):1566-1571.
Yamane, K. ; Miyauchi, T. ; Suzuki, N. ; Yuhara, T. ; Akama, Takao ; Suzuki, H. ; Kashiwagi, H. / Significance of plasma endothelin-1 levels in patients with systemic sclerosis. In: Journal of Rheumatology. 1992 ; Vol. 19, No. 10. pp. 1566-1571.
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