Silefrin, a sodefrin-like pheromone in the abdominal gland of the sword-tailed newt, Cynops ensicauda

Kazutoshi Yamamoto*, Yuka Kawai, Tomoko Hayashi, Yoshihide Ohe, Hiroaki Hayashi, Fumiyo Toyoda, Genri Kawahara, Takeo Iwata, Sakaé Kikuyama

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    74 Citations (Scopus)


    Sodefrin-like female-attracting pheromone was purified from the abdominal glands of male sword-tailed newts, Cynops ensicauda, by gel-filtration chromatography and reversed-phase high-performance liquid chromatography. The final product comprises 10 amino acid residues with the sequence SILSKDAQLK which coincided with the sequence deduced from its precursor cDNA. This peptide was designated silefrin. The sequence of silefrin was different from that of sodefrin by two amino acid residues, with substitutions Leu for Pro and Gln for Leu at positions 3 and 8, respectively. Both native and synthetic silefrin exerted an equipotent activity in attracting conspecific females. Copyright (C) 2000 Federation of European Biochemical Societies.

    Original languageEnglish
    Pages (from-to)267-270
    Number of pages4
    JournalFEBS Letters
    Issue number2-3
    Publication statusPublished - 2000 Apr 28


    • Cynops ensicauda
    • Female-attracting pheromone
    • Purification of silefrin
    • RIA for silefrin
    • Silefrin
    • Sodefrin homologue
    • Sword-tailed newt

    ASJC Scopus subject areas

    • Biochemistry
    • Biophysics
    • Molecular Biology


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