Silicone vascular models for analysis of carotid artery stenting

Y. Okamoto, H. Inukai, H. Kobashi, H. Yamaga, Takanobu Yagi, Kiyotaka Iwasaki, R. Shiurba, Mitsuo Umezu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Carotid artery stenting (CAS) is a minimally invasive surgical treatment for stenosis that is usually due to atherosclerotic plaque. Criteria to select an optimal stent for each clinical situation are lacking, however. Here we describe a surgical simulator that predicts vascular geometries after stenting using silicone rubber models of stenotic carotid arteries. Our objective was to develop the fabrication scheme of such vascular models. Herein, four CAS vascular models, or a soft plaque, two normal, and a hard one, were fabricated. By using rapid prototyping of 3D CT angiographic data, we first made a patient-specific wax models with geometries that matched the lumen of carotid artery. Next, we fabricated a plaque model that matches patient-identical geometries. Then, we produced the each part using silicone rubber with different mechanical properties. In order to match the mechanical properties of the vessel model, pre- and post-stent geometry were compared in vivo and vitro using digital angiography. Moreover, we compared the stiffness of the vessel model by the Young's modulus. We first evaluated the mechanical properties of the vessel, and then that of the plaque. As for the former, the relationship between the expansion ratio and the stiffness parameter β was formulated by curve-fitting. We evaluated the mechanical properties of each plaque. It was found that the Young's modulus were 0.015, 0.092, 0.137, 0.503 N/m2, for the soft, normal (two cases), and hard plaque, respectively. The largest difference was about 34 times for the soft and hard one. We achieved to develop a novel fabrication scheme for the carotid artery with atherosclerotic plaque. The validated vascular model featured two distinct mechanical properties for the vessel and plaque. Such models may help surgeons develop criteria to optimize CAS in a patient-specific manner.

Original languageEnglish
Title of host publicationIFMBE Proceedings
Pages398-401
Number of pages4
Volume31 IFMBE
DOIs
Publication statusPublished - 2010
Event6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech - Singapore
Duration: 2010 Aug 12010 Aug 6

Other

Other6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech
CitySingapore
Period10/8/110/8/6

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Keywords

  • Overexpansion
  • Radial force
  • Restenosis
  • Stent

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

Cite this

Okamoto, Y., Inukai, H., Kobashi, H., Yamaga, H., Yagi, T., Iwasaki, K., Shiurba, R., & Umezu, M. (2010). Silicone vascular models for analysis of carotid artery stenting. In IFMBE Proceedings (Vol. 31 IFMBE, pp. 398-401) https://doi.org/10.1007/978-3-642-14515-5_102