Silver-Catalyzed Efficient Synthesis of Oxindoles and Pyrroloindolines via α-Aminoalkylation of N-Arylacrylamides with Amino Acid Derivatives

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

α-Aminoalkylation of N-arylacrylamides with amino acid derivatives was achieved by silver-catalysis in moderate to high yields. The reaction provides an efficient strategy for the synthesis of functionalized oxindoles, and is suitable for a wide range of N-arylacrylamides and amino acids, both of which are inexpensive and readily available. The oxindoles obtained were readily transformed into densely functionalized pyrroloindolines by deprotection and cyclization in one pot.

Original languageEnglish
Pages (from-to)496-499
Number of pages4
JournalChemistry - An Asian Journal
Volume13
Issue number5
DOIs
Publication statusPublished - 2018 Mar 2

    Fingerprint

Keywords

  • amino acids
  • aminoalkylation
  • C−H activation
  • oxindoles
  • pyrroloindolines
  • silver

ASJC Scopus subject areas

  • Chemistry(all)

Cite this