Abstract
Calorie restriction (CR), which is thought to be largely dependent on the neuroendocrine system modulated by insulin/insulin-like growth factor-I (IGF-I) and leptin signaling, decreases morbidity and increases lifespan in many organisms. To elucidate whether insulin and leptin sensitivities are indispensable in the metabolic adaptation to CR, we investigated the effects of CR on obese Zucker (fa/fa) rats and lean control (+/+) rats. CR did not fully improve insulin resistance in (fa/fa) rats. Nonetheless, CR induced neuropeptide Y (NPY) expression in the hypothalamic arcuate nucleus and metabolism related gene expression changes in the liver in (fa/fa) rats and (+/+) rats. Up-regulation of NPY augmented plasma corticosterone levels and suppressed pituitary growth hormone (GH) expression, thereby modulating adipocytokine production to induce tissue-specific insulin sensitivity. Thus, central NPY activation via peripheral signaling might play a crucial role in the effects of CR, even in insulin resistant and leptin receptor deficient conditions.
| Original language | English |
|---|---|
| Pages (from-to) | 17-25 |
| Number of pages | 9 |
| Journal | Molecular and Cellular Endocrinology |
| Volume | 309 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 2009 Oct 15 |
| Externally published | Yes |
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Keywords
- Glucose and lipid metabolism
- Hypothalamus
- Neuroendocrine
- Oxidative stress
ASJC Scopus subject areas
- Endocrinology
- Molecular Biology
- Biochemistry
Cite this
Similar metabolic responses to calorie restriction in lean and obese Zucker rats. / Chiba, Takuya; Komatsu, Toshimitsu; Nakayama, Masahiko; Adachi, Toshiyuki; Tamashiro, Yukari; Hayashi, Hiroko; Yamaza, Haruyoshi; Higami, Yoshikazu; Shimokawa, Isao.
In: Molecular and Cellular Endocrinology, Vol. 309, No. 1-2, 15.10.2009, p. 17-25.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Similar metabolic responses to calorie restriction in lean and obese Zucker rats
AU - Chiba, Takuya
AU - Komatsu, Toshimitsu
AU - Nakayama, Masahiko
AU - Adachi, Toshiyuki
AU - Tamashiro, Yukari
AU - Hayashi, Hiroko
AU - Yamaza, Haruyoshi
AU - Higami, Yoshikazu
AU - Shimokawa, Isao
PY - 2009/10/15
Y1 - 2009/10/15
N2 - Calorie restriction (CR), which is thought to be largely dependent on the neuroendocrine system modulated by insulin/insulin-like growth factor-I (IGF-I) and leptin signaling, decreases morbidity and increases lifespan in many organisms. To elucidate whether insulin and leptin sensitivities are indispensable in the metabolic adaptation to CR, we investigated the effects of CR on obese Zucker (fa/fa) rats and lean control (+/+) rats. CR did not fully improve insulin resistance in (fa/fa) rats. Nonetheless, CR induced neuropeptide Y (NPY) expression in the hypothalamic arcuate nucleus and metabolism related gene expression changes in the liver in (fa/fa) rats and (+/+) rats. Up-regulation of NPY augmented plasma corticosterone levels and suppressed pituitary growth hormone (GH) expression, thereby modulating adipocytokine production to induce tissue-specific insulin sensitivity. Thus, central NPY activation via peripheral signaling might play a crucial role in the effects of CR, even in insulin resistant and leptin receptor deficient conditions.
AB - Calorie restriction (CR), which is thought to be largely dependent on the neuroendocrine system modulated by insulin/insulin-like growth factor-I (IGF-I) and leptin signaling, decreases morbidity and increases lifespan in many organisms. To elucidate whether insulin and leptin sensitivities are indispensable in the metabolic adaptation to CR, we investigated the effects of CR on obese Zucker (fa/fa) rats and lean control (+/+) rats. CR did not fully improve insulin resistance in (fa/fa) rats. Nonetheless, CR induced neuropeptide Y (NPY) expression in the hypothalamic arcuate nucleus and metabolism related gene expression changes in the liver in (fa/fa) rats and (+/+) rats. Up-regulation of NPY augmented plasma corticosterone levels and suppressed pituitary growth hormone (GH) expression, thereby modulating adipocytokine production to induce tissue-specific insulin sensitivity. Thus, central NPY activation via peripheral signaling might play a crucial role in the effects of CR, even in insulin resistant and leptin receptor deficient conditions.
KW - Glucose and lipid metabolism
KW - Hypothalamus
KW - Neuroendocrine
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=67651172791&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67651172791&partnerID=8YFLogxK
U2 - 10.1016/j.mce.2009.05.001
DO - 10.1016/j.mce.2009.05.001
M3 - Article
C2 - 19446600
AN - SCOPUS:67651172791
VL - 309
SP - 17
EP - 25
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
SN - 0303-7207
IS - 1-2
ER -