Simple action potential measurement of cardiac cell sheet utilizing electronic sheet

Takashi Ohya, Kazuki Nakazono, Tetsutaro Kikuchi, Daisuke Sasaki, Katsuhisa Sakaguchi, Tatsuya Shimizu, Kenjiro Fukuda, Takao Someya, Shinjiro Umezu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In this study, a device for measuring the action potential of cardiac cell sheets was developed. The action potential was measured using a device comprising a 2-µm-thick parylene film with a silver electrode printed on it, which was referred to as the “electronic sheet.” The thin parylene film exhibits high biocompatibility and flexibility. Therefore, it demonstrates promise for biomedical microelectromechanical system applications. In this study, a cell sheet was used because the interest it had garnered in regenerative medicine for creating cardiac tissue in vitro similar to that in vivo. A high-efficiency drug development system can be realized by combining cell sheet technology and fabricating a flexible electronic sheet. The action potential of a cardiac cell sheet from a rat was measured using the as-developed flexible electronic sheet.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalArtificial Life and Robotics
DOIs
Publication statusAccepted/In press - 2018 Mar 21

Fingerprint

Flexible electronics
Action Potentials
Biocompatibility
Silver
Thick films
MEMS
Rats
Tissue
Thin films
Equipment and Supplies
Electrodes
Regenerative Medicine
Pharmaceutical Preparations
Technology
parylene

Keywords

  • Action potential
  • Cell sheet
  • Flexible electronics
  • Printed electronics
  • Regenerative medicine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Artificial Intelligence

Cite this

Simple action potential measurement of cardiac cell sheet utilizing electronic sheet. / Ohya, Takashi; Nakazono, Kazuki; Kikuchi, Tetsutaro; Sasaki, Daisuke; Sakaguchi, Katsuhisa; Shimizu, Tatsuya; Fukuda, Kenjiro; Someya, Takao; Umezu, Shinjiro.

In: Artificial Life and Robotics, 21.03.2018, p. 1-7.

Research output: Contribution to journalArticle

Ohya, Takashi ; Nakazono, Kazuki ; Kikuchi, Tetsutaro ; Sasaki, Daisuke ; Sakaguchi, Katsuhisa ; Shimizu, Tatsuya ; Fukuda, Kenjiro ; Someya, Takao ; Umezu, Shinjiro. / Simple action potential measurement of cardiac cell sheet utilizing electronic sheet. In: Artificial Life and Robotics. 2018 ; pp. 1-7.
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