Abstract
In this study, a device for measuring the action potential of cardiac cell sheets was developed. The action potential was measured using a device comprising a 2-µm-thick parylene film with a silver electrode printed on it, which was referred to as the “electronic sheet.” The thin parylene film exhibits high biocompatibility and flexibility. Therefore, it demonstrates promise for biomedical microelectromechanical system applications. In this study, a cell sheet was used because the interest it had garnered in regenerative medicine for creating cardiac tissue in vitro similar to that in vivo. A high-efficiency drug development system can be realized by combining cell sheet technology and fabricating a flexible electronic sheet. The action potential of a cardiac cell sheet from a rat was measured using the as-developed flexible electronic sheet.
| Original language | English |
|---|---|
| Pages (from-to) | 1-7 |
| Number of pages | 7 |
| Journal | Artificial Life and Robotics |
| DOIs | |
| Publication status | Accepted/In press - 2018 Mar 21 |
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Keywords
- Action potential
- Cell sheet
- Flexible electronics
- Printed electronics
- Regenerative medicine
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Artificial Intelligence
Cite this
Simple action potential measurement of cardiac cell sheet utilizing electronic sheet. / Ohya, Takashi; Nakazono, Kazuki; Kikuchi, Tetsutaro; Sasaki, Daisuke; Sakaguchi, Katsuhisa; Shimizu, Tatsuya; Fukuda, Kenjiro; Someya, Takao; Umezu, Shinjiro.
In: Artificial Life and Robotics, 21.03.2018, p. 1-7.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Simple action potential measurement of cardiac cell sheet utilizing electronic sheet
AU - Ohya, Takashi
AU - Nakazono, Kazuki
AU - Kikuchi, Tetsutaro
AU - Sasaki, Daisuke
AU - Sakaguchi, Katsuhisa
AU - Shimizu, Tatsuya
AU - Fukuda, Kenjiro
AU - Someya, Takao
AU - Umezu, Shinjiro
PY - 2018/3/21
Y1 - 2018/3/21
N2 - In this study, a device for measuring the action potential of cardiac cell sheets was developed. The action potential was measured using a device comprising a 2-µm-thick parylene film with a silver electrode printed on it, which was referred to as the “electronic sheet.” The thin parylene film exhibits high biocompatibility and flexibility. Therefore, it demonstrates promise for biomedical microelectromechanical system applications. In this study, a cell sheet was used because the interest it had garnered in regenerative medicine for creating cardiac tissue in vitro similar to that in vivo. A high-efficiency drug development system can be realized by combining cell sheet technology and fabricating a flexible electronic sheet. The action potential of a cardiac cell sheet from a rat was measured using the as-developed flexible electronic sheet.
AB - In this study, a device for measuring the action potential of cardiac cell sheets was developed. The action potential was measured using a device comprising a 2-µm-thick parylene film with a silver electrode printed on it, which was referred to as the “electronic sheet.” The thin parylene film exhibits high biocompatibility and flexibility. Therefore, it demonstrates promise for biomedical microelectromechanical system applications. In this study, a cell sheet was used because the interest it had garnered in regenerative medicine for creating cardiac tissue in vitro similar to that in vivo. A high-efficiency drug development system can be realized by combining cell sheet technology and fabricating a flexible electronic sheet. The action potential of a cardiac cell sheet from a rat was measured using the as-developed flexible electronic sheet.
KW - Action potential
KW - Cell sheet
KW - Flexible electronics
KW - Printed electronics
KW - Regenerative medicine
UR - http://www.scopus.com/inward/record.url?scp=85044232604&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85044232604&partnerID=8YFLogxK
U2 - 10.1007/s10015-018-0429-y
DO - 10.1007/s10015-018-0429-y
M3 - Article
AN - SCOPUS:85044232604
SP - 1
EP - 7
JO - Artificial Life and Robotics
JF - Artificial Life and Robotics
SN - 1433-5298
ER -