TY - JOUR
T1 - Simple action potential measurement of cardiac cell sheet utilizing electronic sheet
AU - Ohya, Takashi
AU - Nakazono, Kazuki
AU - Kikuchi, Tetsutaro
AU - Sasaki, Daisuke
AU - Sakaguchi, Katsuhisa
AU - Shimizu, Tatsuya
AU - Fukuda, Kenjiro
AU - Someya, Takao
AU - Umezu, Shinjiro
N1 - Funding Information:
T. Shimizu is a member of Scientific Advisory Board of CellSeed Inc. and is a shareholder of CellSeed Inc. CellSeed Inc. has licenses for certain cell sheet-related technologies and patents from Tokyo Women?s Medical University. Tokyo Women?s Medical University received research funds from CellSeed Inc. This work was supported by JSPS Kakenhi Grant number 16H04308 and 16K14203. This work was presented in part at the 2nd International Symposium on BioComplexity, Beppu, Oita, January 19?21, 2017.
Funding Information:
Acknowledgements T. Shimizu is a member of Scientific Advisory Board of CellSeed Inc. and is a shareholder of CellSeed Inc. CellSeed Inc. has licenses for certain cell sheet-related technologies and patents from Tokyo Women’s Medical University. Tokyo Women’s Medical University received research funds from CellSeed Inc. This work was supported by JSPS Kakenhi Grant number 16H04308 and 16K14203.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - In this study, a device for measuring the action potential of cardiac cell sheets was developed. The action potential was measured using a device comprising a 2-µm-thick parylene film with a silver electrode printed on it, which was referred to as the “electronic sheet.” The thin parylene film exhibits high biocompatibility and flexibility. Therefore, it demonstrates promise for biomedical microelectromechanical system applications. In this study, a cell sheet was used because the interest it had garnered in regenerative medicine for creating cardiac tissue in vitro similar to that in vivo. A high-efficiency drug development system can be realized by combining cell sheet technology and fabricating a flexible electronic sheet. The action potential of a cardiac cell sheet from a rat was measured using the as-developed flexible electronic sheet.
AB - In this study, a device for measuring the action potential of cardiac cell sheets was developed. The action potential was measured using a device comprising a 2-µm-thick parylene film with a silver electrode printed on it, which was referred to as the “electronic sheet.” The thin parylene film exhibits high biocompatibility and flexibility. Therefore, it demonstrates promise for biomedical microelectromechanical system applications. In this study, a cell sheet was used because the interest it had garnered in regenerative medicine for creating cardiac tissue in vitro similar to that in vivo. A high-efficiency drug development system can be realized by combining cell sheet technology and fabricating a flexible electronic sheet. The action potential of a cardiac cell sheet from a rat was measured using the as-developed flexible electronic sheet.
KW - Action potential
KW - Cell sheet
KW - Flexible electronics
KW - Printed electronics
KW - Regenerative medicine
UR - http://www.scopus.com/inward/record.url?scp=85044232604&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85044232604&partnerID=8YFLogxK
U2 - 10.1007/s10015-018-0429-y
DO - 10.1007/s10015-018-0429-y
M3 - Article
AN - SCOPUS:85044232604
VL - 23
SP - 321
EP - 327
JO - Artificial Life and Robotics
JF - Artificial Life and Robotics
SN - 1433-5298
IS - 3
ER -