Simultaneous comparison of thrombogenic reactions to different combinations of anticoagulants, activated clotting times, and materials

Mirei Nagai, Kiyotaka Iwasaki, Mitsuo Umezu, Makoto Ozaki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Thrombogenic reactions under multiple interactions of pharmacological agents, doses, and materials have not been well understood yet. The aim of this study was to investigate the ability to simultaneously compare thrombogenic reactions to different combinations of anticoagulants, doses, and blood-contacting materials, in a single human blood using an in vitro test method. Four venous blood samples were drawn from each of six healthy volunteers into syringes that contained two different amounts of heparin and argatroban to set the activated clotting time (ACT) to approximately 200 or 500 s, respectively. The four blood samples from each volunteer were immediately poured into two clinical-grade extracorporeal circulation tubes: a polyvinyl chloride (PVC) tube and a poly(2-methoxyethyl acrylate)-coated (PMEA) PVC tube. These tubes with an inner diameter of 12.7 mm were rotated at 183 rpm in a 37

Original languageEnglish
Pages (from-to)1605-1612
Number of pages8
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume102
Issue number8
DOIs
Publication statusPublished - 2014 Nov 1

Keywords

  • Activated clotting time
  • Anticoagulant
  • In vitro thrombogenicity test
  • Platelet activation
  • Total plasma protein adsorption

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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