Single bout of exercise eliminates the immobilization-induced oxidative stress in rat brain

Zsolt Radak, Maria Sasvari, Csaba Nyakas, Takao Kaneko, Shoichi Tahara, Hideki Ohno, Sataro Goto

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

We were interested in the effects of immobilization (IM), a single bout of exercise (E) and immobilization followed by exercise (EIM) on memory and oxidative damage of macromolecules in hippocampus of rat brain. Eight hours of IM resulted in impairment of passive avoidance test (memory retrieval deficit) and increased latency to start locomotion in an open-field test. Two hours of swimming did not significantly alter the memory retrieval deficit and latency, while the EIM group had longer latency and similar memory than control and E groups. The oxidative damage of lipids, proteins and nuclear DNA increased significantly in IM group and no increase was observed in E and EIM animals. The activity of proteasome was not altered in any groups. The activity of glutamine synthetase (GS) was decreased in IM group (P < 0.05), this down regulation was not observed in E and EIM groups. These data suggest that oxidative damage of macromolecules is associated with impaired cognitive function. Single bout of exercise after immobilization eliminates the oxidative damage of macromolecules and normalizes memory function, probably by its ability to restore the activity level of GS and eliminate the consequences of immobilization-induced prolonged efflux of glutamate.

Original languageEnglish
Pages (from-to)33-38
Number of pages6
JournalNeurochemistry International
Volume39
Issue number1
DOIs
Publication statusPublished - 2001 Apr 26
Externally publishedYes

Fingerprint

Immobilization
Oxidative Stress
Brain
Glutamate-Ammonia Ligase
Memory Disorders
Aptitude
Proteasome Endopeptidase Complex
Locomotion
Nuclear Proteins
Cognition
Glutamic Acid
Hippocampus
Down-Regulation
Lipids
Control Groups
DNA

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Single bout of exercise eliminates the immobilization-induced oxidative stress in rat brain. / Radak, Zsolt; Sasvari, Maria; Nyakas, Csaba; Kaneko, Takao; Tahara, Shoichi; Ohno, Hideki; Goto, Sataro.

In: Neurochemistry International, Vol. 39, No. 1, 26.04.2001, p. 33-38.

Research output: Contribution to journalArticle

Radak, Zsolt ; Sasvari, Maria ; Nyakas, Csaba ; Kaneko, Takao ; Tahara, Shoichi ; Ohno, Hideki ; Goto, Sataro. / Single bout of exercise eliminates the immobilization-induced oxidative stress in rat brain. In: Neurochemistry International. 2001 ; Vol. 39, No. 1. pp. 33-38.
@article{0d50e68ee223462cac68efb5d8156c6a,
title = "Single bout of exercise eliminates the immobilization-induced oxidative stress in rat brain",
abstract = "We were interested in the effects of immobilization (IM), a single bout of exercise (E) and immobilization followed by exercise (EIM) on memory and oxidative damage of macromolecules in hippocampus of rat brain. Eight hours of IM resulted in impairment of passive avoidance test (memory retrieval deficit) and increased latency to start locomotion in an open-field test. Two hours of swimming did not significantly alter the memory retrieval deficit and latency, while the EIM group had longer latency and similar memory than control and E groups. The oxidative damage of lipids, proteins and nuclear DNA increased significantly in IM group and no increase was observed in E and EIM animals. The activity of proteasome was not altered in any groups. The activity of glutamine synthetase (GS) was decreased in IM group (P < 0.05), this down regulation was not observed in E and EIM groups. These data suggest that oxidative damage of macromolecules is associated with impaired cognitive function. Single bout of exercise after immobilization eliminates the oxidative damage of macromolecules and normalizes memory function, probably by its ability to restore the activity level of GS and eliminate the consequences of immobilization-induced prolonged efflux of glutamate.",
author = "Zsolt Radak and Maria Sasvari and Csaba Nyakas and Takao Kaneko and Shoichi Tahara and Hideki Ohno and Sataro Goto",
year = "2001",
month = "4",
day = "26",
doi = "10.1016/S0197-0186(01)00003-1",
language = "English",
volume = "39",
pages = "33--38",
journal = "Neurochemistry International",
issn = "0197-0186",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - Single bout of exercise eliminates the immobilization-induced oxidative stress in rat brain

AU - Radak, Zsolt

AU - Sasvari, Maria

AU - Nyakas, Csaba

AU - Kaneko, Takao

AU - Tahara, Shoichi

AU - Ohno, Hideki

AU - Goto, Sataro

PY - 2001/4/26

Y1 - 2001/4/26

N2 - We were interested in the effects of immobilization (IM), a single bout of exercise (E) and immobilization followed by exercise (EIM) on memory and oxidative damage of macromolecules in hippocampus of rat brain. Eight hours of IM resulted in impairment of passive avoidance test (memory retrieval deficit) and increased latency to start locomotion in an open-field test. Two hours of swimming did not significantly alter the memory retrieval deficit and latency, while the EIM group had longer latency and similar memory than control and E groups. The oxidative damage of lipids, proteins and nuclear DNA increased significantly in IM group and no increase was observed in E and EIM animals. The activity of proteasome was not altered in any groups. The activity of glutamine synthetase (GS) was decreased in IM group (P < 0.05), this down regulation was not observed in E and EIM groups. These data suggest that oxidative damage of macromolecules is associated with impaired cognitive function. Single bout of exercise after immobilization eliminates the oxidative damage of macromolecules and normalizes memory function, probably by its ability to restore the activity level of GS and eliminate the consequences of immobilization-induced prolonged efflux of glutamate.

AB - We were interested in the effects of immobilization (IM), a single bout of exercise (E) and immobilization followed by exercise (EIM) on memory and oxidative damage of macromolecules in hippocampus of rat brain. Eight hours of IM resulted in impairment of passive avoidance test (memory retrieval deficit) and increased latency to start locomotion in an open-field test. Two hours of swimming did not significantly alter the memory retrieval deficit and latency, while the EIM group had longer latency and similar memory than control and E groups. The oxidative damage of lipids, proteins and nuclear DNA increased significantly in IM group and no increase was observed in E and EIM animals. The activity of proteasome was not altered in any groups. The activity of glutamine synthetase (GS) was decreased in IM group (P < 0.05), this down regulation was not observed in E and EIM groups. These data suggest that oxidative damage of macromolecules is associated with impaired cognitive function. Single bout of exercise after immobilization eliminates the oxidative damage of macromolecules and normalizes memory function, probably by its ability to restore the activity level of GS and eliminate the consequences of immobilization-induced prolonged efflux of glutamate.

UR - http://www.scopus.com/inward/record.url?scp=0035052302&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035052302&partnerID=8YFLogxK

U2 - 10.1016/S0197-0186(01)00003-1

DO - 10.1016/S0197-0186(01)00003-1

M3 - Article

VL - 39

SP - 33

EP - 38

JO - Neurochemistry International

JF - Neurochemistry International

SN - 0197-0186

IS - 1

ER -