Single-cell-based electrophysiological measurement of a topographically controlled neuronal network using agarose architecture with a multi-electrode array

Ikurou Suzuki, Yoshihiro Sugio, Yasuhiko Jimbo, Kenji Yasuda

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The measurement of topographically-controlled neuronal networks using a single-cell-based on-chip multi-electrode array (MEA) cell cultivation system with an agarose microchamber (AMC) array is discussed. The system enables flexible and precise control of the cell positions for cultivation using AMCs, and the pattern of connections between AMCs through photo-thermal etching. With adequate laser power, narrow micrometer-order grooves can be fabricated during cultivation that can be used to combine neighboring AMCs, enabling comparison of the network response of the neural network patterns with patterns of rat hippocampal cells. The method opens potential applications for the next stage single-cell-based neural networks in the biomedical fields.

Original languageEnglish
Title of host publicationDigest of Papers - Microprocesses and Nanotechnology 2004
Pages220-221
Number of pages2
Publication statusPublished - 2004
Externally publishedYes
Event2004 International Microprocesses and Nanotechnology Conference - Osaka
Duration: 2004 Oct 262004 Oct 29

Other

Other2004 International Microprocesses and Nanotechnology Conference
CityOsaka
Period04/10/2604/10/29

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ASJC Scopus subject areas

  • Engineering(all)

Cite this

Suzuki, I., Sugio, Y., Jimbo, Y., & Yasuda, K. (2004). Single-cell-based electrophysiological measurement of a topographically controlled neuronal network using agarose architecture with a multi-electrode array. In Digest of Papers - Microprocesses and Nanotechnology 2004 (pp. 220-221)