Single Dose Administration of Taheebo Polyphenol Enhances Endurance Capacity in Mice

Koichi Yada, Katsuhiko Suzuki, Natsumi Oginome, Sihui Ma, Youichi Fukuda, Akira Iida, Zsolt Radak

Research output: Contribution to journalArticle

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Abstract

Endurance capacity is important for maintenance of quality of life as well as performance of endurance athletes. In order to improve endurance, intake of nutritional supplements as well as exercise training is also important. Indeed, polyphenolic extracts from plants are known to improve endurance capacity via increase of fatty acid utilization, mitochondrial biogenesis or inhibition of oxidative stress. Taheebo, the extract obtained from inner bark of Tabebuia avellanedae has been reported to have beneficial effects for treatment of inflammation, oxidative stress and obesity. Here, we investigated the effects and mechanisms of polyphenol fraction of taheebo (taheebo polyphenol; TP) on endurance capacity of mice. Single dose administration of TP significantly increased running time until exhaustion. Acute TP administration increased blood glucose and muscle glycogen levels (p < 0.05) through alteration on expression level of genes involved with glycogen metabolism and gluconeogenesis. Furthermore, TP administration decreased exercise-induced increase of protein carbonyls in skeletal muscle. These results suggest that TP administration improve endurance capacity via up-regulation of skeletal muscle glycogen levels and maintenance of blood glucose by acceleration of gluconeogenesis as well as inhibition of exercise-induced oxidative stress. Single administration of TP also increased phosphorylation of AMP-activated protein kinase (AMPK) and gene expression level of sirtuin 1 (SIRT1) but did not change the marker of mitochondrial biogenesis.

Original languageEnglish
Article number14625
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - 2018 Dec 1

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Polyphenols
Glycogen
Oxidative Stress
Gluconeogenesis
Organelle Biogenesis
Exercise
Blood Glucose
Tabebuia
Skeletal Muscle
Sirtuin 1
Gene Expression
AMP-Activated Protein Kinases
Plant Extracts
Running
Athletes
Up-Regulation
Fatty Acids
Obesity
Maintenance
Phosphorylation

ASJC Scopus subject areas

  • General

Cite this

Single Dose Administration of Taheebo Polyphenol Enhances Endurance Capacity in Mice. / Yada, Koichi; Suzuki, Katsuhiko; Oginome, Natsumi; Ma, Sihui; Fukuda, Youichi; Iida, Akira; Radak, Zsolt.

In: Scientific Reports, Vol. 8, No. 1, 14625, 01.12.2018.

Research output: Contribution to journalArticle

Yada, Koichi ; Suzuki, Katsuhiko ; Oginome, Natsumi ; Ma, Sihui ; Fukuda, Youichi ; Iida, Akira ; Radak, Zsolt. / Single Dose Administration of Taheebo Polyphenol Enhances Endurance Capacity in Mice. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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