Single lung transplantation in rats with fatal pulmonary hypertension

A. T. Kawaguchi, Y. Kawashima, T. Mizuta, H. Ishibashi-Ueda, Kazuyuki Kanosue, R. Shirakura, H. Matsuda

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Effects of single lung transplantation on fatal pulmonary hypertension were evaluated in rats receiving a lethal dose of monocrotaline. Inbred rats treated with monocrotaline (80 mg/kg) received a left lung isograft at 4 weeks (n = 9) and at 6 weeks (n = 6), when moderate and severe pulmonary hypertension, respectively, had developed. Medicated (n = 12) and nonmedicated rats (n = 12) served as control animals. Each rat was tested weekly with treadmill for exercise tolerance and oxygen consumption during a 10-week period after medication and after they were killed. Medicated control rats lost exercise tolerance and highest oxygen consumption per unit time consistently to the range of resting value (or 45% of nonmedicated control rats), and all died from severe pulmonary vascular occlusive disease with right ventricular hypertrophy before 10 weeks (right ventricular/left ventricular weight ratio of 1.16). All rats receiving a left lung isograft at 4 weeks survived and regained highest oxygen consumption per unit time (87% of nonmedicated control rats), with the lung transplant receiving 65% (nonmedicated control rats, 39%) of cardiac output and milder right ventricular hypertrophy (right ventricular/left ventricular weight ratio of 0.46). Except for one, all rats that received a left lung isograft at 6 weeks tolerated single lung transplantation, but they died soon after reperfusion because of pulmonary edema in the graft that received 58% of cardiac output with right ventricular/left ventricular weight ratio of 0.79. Results of single lung transplantation in rats were dependent on severity of pulmonary hypertension. In rats with moderate pulmonary hypertension, single lung transplantation was successful in reversing exercise intolerance and right ventricular hypertrophy. Single lung transplantation was unsuccessful when pulmonary hypertension was severe in the rat model because increased flow toward the lung transplant resulted in graft pulmonary edema.

Original languageEnglish
Pages (from-to)825-829
Number of pages5
JournalJournal of Thoracic and Cardiovascular Surgery
Volume104
Issue number3
Publication statusPublished - 1992 Jan 1
Externally publishedYes

Fingerprint

Lung Transplantation
Pulmonary Hypertension
Isografts
Right Ventricular Hypertrophy
Lung
Oxygen Consumption
Monocrotaline
Transplants
Exercise Tolerance
Pulmonary Edema
Weights and Measures
Cardiac Output
Vascular Diseases
Reperfusion

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Kawaguchi, A. T., Kawashima, Y., Mizuta, T., Ishibashi-Ueda, H., Kanosue, K., Shirakura, R., & Matsuda, H. (1992). Single lung transplantation in rats with fatal pulmonary hypertension. Journal of Thoracic and Cardiovascular Surgery, 104(3), 825-829.

Single lung transplantation in rats with fatal pulmonary hypertension. / Kawaguchi, A. T.; Kawashima, Y.; Mizuta, T.; Ishibashi-Ueda, H.; Kanosue, Kazuyuki; Shirakura, R.; Matsuda, H.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 104, No. 3, 01.01.1992, p. 825-829.

Research output: Contribution to journalArticle

Kawaguchi, AT, Kawashima, Y, Mizuta, T, Ishibashi-Ueda, H, Kanosue, K, Shirakura, R & Matsuda, H 1992, 'Single lung transplantation in rats with fatal pulmonary hypertension', Journal of Thoracic and Cardiovascular Surgery, vol. 104, no. 3, pp. 825-829.
Kawaguchi AT, Kawashima Y, Mizuta T, Ishibashi-Ueda H, Kanosue K, Shirakura R et al. Single lung transplantation in rats with fatal pulmonary hypertension. Journal of Thoracic and Cardiovascular Surgery. 1992 Jan 1;104(3):825-829.
Kawaguchi, A. T. ; Kawashima, Y. ; Mizuta, T. ; Ishibashi-Ueda, H. ; Kanosue, Kazuyuki ; Shirakura, R. ; Matsuda, H. / Single lung transplantation in rats with fatal pulmonary hypertension. In: Journal of Thoracic and Cardiovascular Surgery. 1992 ; Vol. 104, No. 3. pp. 825-829.
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