Single walled carbon nanotubes based regulation of proliferation and differentiation of mouse embryonic stem cells

Daxiang Cui, Z. Wang, H. Zhang, J. Ruan, C. C. Bao, H. Yang, Toru Asahi, H. Song, K. Wang

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    1 Citation (Scopus)

    Abstract

    Carbon nanotubes'bio-effects have become a hotspot. In recent years, my group and collaborators try to use single walled carbon nanotubes(SWCNTs) as drug delivery system to regulate proliferation and differentiation of mouse stem cells. We observed that low dose of SWCNTs stimulate stem cells'proliferation and differentiation, higher dose of SWCNTs improve stem cells' apoptosis. Y-27632, a selective inhibitor of p160 Rho-associated coiled-coil kinase, can conjugate with SWCNTs and form the nanocomposites, which markedly inhibit the apoptosis of mouse stem cells, improve the proliferation and differentiation of stem cells. The potential mechanism of effects of Y-27632-SWCNT composites on stem cells is also dicussed. Our primary results suggest that special enzyme modified SWCNTs can be used to regulate proliferation and differentiation of stem cells, which has potential application in stem cells-based therapy.

    Original languageEnglish
    Title of host publicationECS Transactions
    Pages63-67
    Number of pages5
    Volume19
    Edition13
    DOIs
    Publication statusPublished - 2009
    EventCarbon Nanotubes and Nanostructures: Fundam. Properties and Processes; Carbon Nanotubes and Nanostructures: Appl. and Devices; Carbon Nanotubes and Nanostructures: Medicine and Biology and Porphyrins and Supramolecular Assemblies - 215th ECS Meeting - San Francisco, CA
    Duration: 2009 May 242009 May 29

    Other

    OtherCarbon Nanotubes and Nanostructures: Fundam. Properties and Processes; Carbon Nanotubes and Nanostructures: Appl. and Devices; Carbon Nanotubes and Nanostructures: Medicine and Biology and Porphyrins and Supramolecular Assemblies - 215th ECS Meeting
    CitySan Francisco, CA
    Period09/5/2409/5/29

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    ASJC Scopus subject areas

    • Engineering(all)

    Cite this

    Cui, D., Wang, Z., Zhang, H., Ruan, J., Bao, C. C., Yang, H., Asahi, T., Song, H., & Wang, K. (2009). Single walled carbon nanotubes based regulation of proliferation and differentiation of mouse embryonic stem cells. In ECS Transactions (13 ed., Vol. 19, pp. 63-67) https://doi.org/10.1149/1.3236795