Single walled carbon nanotubes based regulation of proliferation and differentiation of mouse embryonic stem cells

Daxiang Cui, Z. Wang, H. Zhang, J. Ruan, C. C. Bao, H. Yang, Toru Asahi, H. Song, K. Wang

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    1 Citation (Scopus)

    Abstract

    Carbon nanotubes'bio-effects have become a hotspot. In recent years, my group and collaborators try to use single walled carbon nanotubes(SWCNTs) as drug delivery system to regulate proliferation and differentiation of mouse stem cells. We observed that low dose of SWCNTs stimulate stem cells'proliferation and differentiation, higher dose of SWCNTs improve stem cells' apoptosis. Y-27632, a selective inhibitor of p160 Rho-associated coiled-coil kinase, can conjugate with SWCNTs and form the nanocomposites, which markedly inhibit the apoptosis of mouse stem cells, improve the proliferation and differentiation of stem cells. The potential mechanism of effects of Y-27632-SWCNT composites on stem cells is also dicussed. Our primary results suggest that special enzyme modified SWCNTs can be used to regulate proliferation and differentiation of stem cells, which has potential application in stem cells-based therapy.

    Original languageEnglish
    Title of host publicationECS Transactions
    Pages63-67
    Number of pages5
    Volume19
    Edition13
    DOIs
    Publication statusPublished - 2009
    EventCarbon Nanotubes and Nanostructures: Fundam. Properties and Processes; Carbon Nanotubes and Nanostructures: Appl. and Devices; Carbon Nanotubes and Nanostructures: Medicine and Biology and Porphyrins and Supramolecular Assemblies - 215th ECS Meeting - San Francisco, CA
    Duration: 2009 May 242009 May 29

    Other

    OtherCarbon Nanotubes and Nanostructures: Fundam. Properties and Processes; Carbon Nanotubes and Nanostructures: Appl. and Devices; Carbon Nanotubes and Nanostructures: Medicine and Biology and Porphyrins and Supramolecular Assemblies - 215th ECS Meeting
    CitySan Francisco, CA
    Period09/5/2409/5/29

    Fingerprint

    Single-walled carbon nanotubes (SWCN)
    Stem cells
    Cell death
    Cell proliferation
    Carbon nanotubes
    Nanocomposites
    Enzymes
    Composite materials

    ASJC Scopus subject areas

    • Engineering(all)

    Cite this

    Cui, D., Wang, Z., Zhang, H., Ruan, J., Bao, C. C., Yang, H., ... Wang, K. (2009). Single walled carbon nanotubes based regulation of proliferation and differentiation of mouse embryonic stem cells. In ECS Transactions (13 ed., Vol. 19, pp. 63-67) https://doi.org/10.1149/1.3236795

    Single walled carbon nanotubes based regulation of proliferation and differentiation of mouse embryonic stem cells. / Cui, Daxiang; Wang, Z.; Zhang, H.; Ruan, J.; Bao, C. C.; Yang, H.; Asahi, Toru; Song, H.; Wang, K.

    ECS Transactions. Vol. 19 13. ed. 2009. p. 63-67.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Cui, D, Wang, Z, Zhang, H, Ruan, J, Bao, CC, Yang, H, Asahi, T, Song, H & Wang, K 2009, Single walled carbon nanotubes based regulation of proliferation and differentiation of mouse embryonic stem cells. in ECS Transactions. 13 edn, vol. 19, pp. 63-67, Carbon Nanotubes and Nanostructures: Fundam. Properties and Processes; Carbon Nanotubes and Nanostructures: Appl. and Devices; Carbon Nanotubes and Nanostructures: Medicine and Biology and Porphyrins and Supramolecular Assemblies - 215th ECS Meeting, San Francisco, CA, 09/5/24. https://doi.org/10.1149/1.3236795
    Cui D, Wang Z, Zhang H, Ruan J, Bao CC, Yang H et al. Single walled carbon nanotubes based regulation of proliferation and differentiation of mouse embryonic stem cells. In ECS Transactions. 13 ed. Vol. 19. 2009. p. 63-67 https://doi.org/10.1149/1.3236795
    Cui, Daxiang ; Wang, Z. ; Zhang, H. ; Ruan, J. ; Bao, C. C. ; Yang, H. ; Asahi, Toru ; Song, H. ; Wang, K. / Single walled carbon nanotubes based regulation of proliferation and differentiation of mouse embryonic stem cells. ECS Transactions. Vol. 19 13. ed. 2009. pp. 63-67
    @inproceedings{313a66fd67954ad8853da91a36a9bff3,
    title = "Single walled carbon nanotubes based regulation of proliferation and differentiation of mouse embryonic stem cells",
    abstract = "Carbon nanotubes'bio-effects have become a hotspot. In recent years, my group and collaborators try to use single walled carbon nanotubes(SWCNTs) as drug delivery system to regulate proliferation and differentiation of mouse stem cells. We observed that low dose of SWCNTs stimulate stem cells'proliferation and differentiation, higher dose of SWCNTs improve stem cells' apoptosis. Y-27632, a selective inhibitor of p160 Rho-associated coiled-coil kinase, can conjugate with SWCNTs and form the nanocomposites, which markedly inhibit the apoptosis of mouse stem cells, improve the proliferation and differentiation of stem cells. The potential mechanism of effects of Y-27632-SWCNT composites on stem cells is also dicussed. Our primary results suggest that special enzyme modified SWCNTs can be used to regulate proliferation and differentiation of stem cells, which has potential application in stem cells-based therapy.",
    author = "Daxiang Cui and Z. Wang and H. Zhang and J. Ruan and Bao, {C. C.} and H. Yang and Toru Asahi and H. Song and K. Wang",
    year = "2009",
    doi = "10.1149/1.3236795",
    language = "English",
    isbn = "9781607681052",
    volume = "19",
    pages = "63--67",
    booktitle = "ECS Transactions",
    edition = "13",

    }

    TY - GEN

    T1 - Single walled carbon nanotubes based regulation of proliferation and differentiation of mouse embryonic stem cells

    AU - Cui, Daxiang

    AU - Wang, Z.

    AU - Zhang, H.

    AU - Ruan, J.

    AU - Bao, C. C.

    AU - Yang, H.

    AU - Asahi, Toru

    AU - Song, H.

    AU - Wang, K.

    PY - 2009

    Y1 - 2009

    N2 - Carbon nanotubes'bio-effects have become a hotspot. In recent years, my group and collaborators try to use single walled carbon nanotubes(SWCNTs) as drug delivery system to regulate proliferation and differentiation of mouse stem cells. We observed that low dose of SWCNTs stimulate stem cells'proliferation and differentiation, higher dose of SWCNTs improve stem cells' apoptosis. Y-27632, a selective inhibitor of p160 Rho-associated coiled-coil kinase, can conjugate with SWCNTs and form the nanocomposites, which markedly inhibit the apoptosis of mouse stem cells, improve the proliferation and differentiation of stem cells. The potential mechanism of effects of Y-27632-SWCNT composites on stem cells is also dicussed. Our primary results suggest that special enzyme modified SWCNTs can be used to regulate proliferation and differentiation of stem cells, which has potential application in stem cells-based therapy.

    AB - Carbon nanotubes'bio-effects have become a hotspot. In recent years, my group and collaborators try to use single walled carbon nanotubes(SWCNTs) as drug delivery system to regulate proliferation and differentiation of mouse stem cells. We observed that low dose of SWCNTs stimulate stem cells'proliferation and differentiation, higher dose of SWCNTs improve stem cells' apoptosis. Y-27632, a selective inhibitor of p160 Rho-associated coiled-coil kinase, can conjugate with SWCNTs and form the nanocomposites, which markedly inhibit the apoptosis of mouse stem cells, improve the proliferation and differentiation of stem cells. The potential mechanism of effects of Y-27632-SWCNT composites on stem cells is also dicussed. Our primary results suggest that special enzyme modified SWCNTs can be used to regulate proliferation and differentiation of stem cells, which has potential application in stem cells-based therapy.

    UR - http://www.scopus.com/inward/record.url?scp=79955625040&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=79955625040&partnerID=8YFLogxK

    U2 - 10.1149/1.3236795

    DO - 10.1149/1.3236795

    M3 - Conference contribution

    SN - 9781607681052

    VL - 19

    SP - 63

    EP - 67

    BT - ECS Transactions

    ER -