Single walled carbon nanotubes based regulation of proliferation and differentiation of mouse embryonic stem cells

Daxiang Cui*, Z. Wang, H. Zhang, J. Ruan, C. C. Bao, H. Yang, Asahi Toru, H. Song, K. Wang

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Carbon nanotubes'bio-effects have become a hotspot. In recent years, my group and collaborators try to use single walled carbon nanotubes(SWCNTs) as drug delivery system to regulate proliferation and differentiation of mouse stem cells. We observed that low dose of SWCNTs stimulate stem cells'proliferation and differentiation, higher dose of SWCNTs improve stem cells' apoptosis. Y-27632, a selective inhibitor of p160 Rho-associated coiled-coil kinase, can conjugate with SWCNTs and form the nanocomposites, which markedly inhibit the apoptosis of mouse stem cells, improve the proliferation and differentiation of stem cells. The potential mechanism of effects of Y-27632-SWCNT composites on stem cells is also dicussed. Our primary results suggest that special enzyme modified SWCNTs can be used to regulate proliferation and differentiation of stem cells, which has potential application in stem cells-based therapy.

Original languageEnglish
Title of host publicationFullerenes, Nanotubes, and Carbon Nanostructures - 215th ECS Meeting
PublisherElectrochemical Society Inc.
Pages63-67
Number of pages5
Edition13
ISBN (Electronic)9781566777551
ISBN (Print)9781607681052
DOIs
Publication statusPublished - 2009

Publication series

NameECS Transactions
Number13
Volume19
ISSN (Print)1938-5862
ISSN (Electronic)1938-6737

ASJC Scopus subject areas

  • Engineering(all)

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