TY - JOUR
T1 - Skeletal muscle adaptation in response to mechanical stress in p130cas-/-mice
AU - Akimoto, Takayuki
AU - Okuhira, Kanako
AU - Aizawa, Katsuji
AU - Wada, Shogo
AU - Honda, Hiroaki
AU - Fukubayashi, Toru
AU - Ushida, Takashi
PY - 2013
Y1 - 2013
N2 - Mammalian skeletal muscles undergo adaptation in response to changes in the functional demands upon them, involving mechanical-stress-induced cellular signaling called "mechanotransduction." We hypothesized that p130Cas, which is reported to act as a mechanosensor that transduces mechanical extension into cellular signaling, plays an important role in maintaining and promoting skeletal muscle adapta-tion in response to mechanical stress via the p38 MAPK signaling pathway. We demonstrate that muscle-specific p130Cas-/-mice express the contractile proteins normally in skeletal muscle. Further-more, muscle-specific p130Cas-/-mice show normal mechanical-stress-induced muscle adaptation, including exercise-induced IIb-to-IIa muscle fiber type transformation and hypertrophy. Finally, we provide evidence that exercise-induced p38 MAPK signaling is not impaired by the muscle-specific deletion of p130Cas. We conclude that p130Cas plays a limited role in mechanical-stress-induced skel-etal muscle adaptation.
AB - Mammalian skeletal muscles undergo adaptation in response to changes in the functional demands upon them, involving mechanical-stress-induced cellular signaling called "mechanotransduction." We hypothesized that p130Cas, which is reported to act as a mechanosensor that transduces mechanical extension into cellular signaling, plays an important role in maintaining and promoting skeletal muscle adapta-tion in response to mechanical stress via the p38 MAPK signaling pathway. We demonstrate that muscle-specific p130Cas-/-mice express the contractile proteins normally in skeletal muscle. Further-more, muscle-specific p130Cas-/-mice show normal mechanical-stress-induced muscle adaptation, including exercise-induced IIb-to-IIa muscle fiber type transformation and hypertrophy. Finally, we provide evidence that exercise-induced p38 MAPK signaling is not impaired by the muscle-specific deletion of p130Cas. We conclude that p130Cas plays a limited role in mechanical-stress-induced skel-etal muscle adaptation.
KW - Mechanotransduction
KW - Muscle fiber type
KW - P38 MAPK
KW - Peroxisome proliferator-activated receptor-γ coactivator-1α
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UR - http://www.scopus.com/inward/citedby.url?scp=84877295713&partnerID=8YFLogxK
U2 - 10.1152/ajpcell.00243.2012
DO - 10.1152/ajpcell.00243.2012
M3 - Article
C2 - 23325412
AN - SCOPUS:84877295713
VL - 304
SP - C541-C547
JO - American Journal of Physiology - Cell Physiology
JF - American Journal of Physiology - Cell Physiology
SN - 0363-6143
IS - 6
ER -