Abstract
Mammalian skeletal muscles undergo adaptation in response to changes in the functional demands upon them, involving mechanical-stress-induced cellular signaling called "mechanotransduction." We hypothesized that p130Cas, which is reported to act as a mechanosensor that transduces mechanical extension into cellular signaling, plays an important role in maintaining and promoting skeletal muscle adapta-tion in response to mechanical stress via the p38 MAPK signaling pathway. We demonstrate that muscle-specific p130Cas-/-mice express the contractile proteins normally in skeletal muscle. Further-more, muscle-specific p130Cas-/-mice show normal mechanical-stress-induced muscle adaptation, including exercise-induced IIb-to-IIa muscle fiber type transformation and hypertrophy. Finally, we provide evidence that exercise-induced p38 MAPK signaling is not impaired by the muscle-specific deletion of p130Cas. We conclude that p130Cas plays a limited role in mechanical-stress-induced skel-etal muscle adaptation.
| Original language | English |
|---|---|
| Journal | American Journal of Physiology - Cell Physiology |
| Volume | 304 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2013 |
| Externally published | Yes |
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Keywords
- Mechanotransduction
- Muscle fiber type
- P38 MAPK
- Peroxisome proliferator-activated receptor-γ coactivator-1α
ASJC Scopus subject areas
- Cell Biology
- Physiology
- Medicine(all)
Cite this
Skeletal muscle adaptation in response to mechanical stress in p130cas-/-mice. / Akimoto, Takayuki; Okuhira, Kanako; Aizawa, Katsuji; Wada, Shogo; Honda, Hiroaki; Fukubayashi, Toru; Ushida, Takashi.
In: American Journal of Physiology - Cell Physiology, Vol. 304, No. 6, 2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Skeletal muscle adaptation in response to mechanical stress in p130cas-/-mice
AU - Akimoto, Takayuki
AU - Okuhira, Kanako
AU - Aizawa, Katsuji
AU - Wada, Shogo
AU - Honda, Hiroaki
AU - Fukubayashi, Toru
AU - Ushida, Takashi
PY - 2013
Y1 - 2013
N2 - Mammalian skeletal muscles undergo adaptation in response to changes in the functional demands upon them, involving mechanical-stress-induced cellular signaling called "mechanotransduction." We hypothesized that p130Cas, which is reported to act as a mechanosensor that transduces mechanical extension into cellular signaling, plays an important role in maintaining and promoting skeletal muscle adapta-tion in response to mechanical stress via the p38 MAPK signaling pathway. We demonstrate that muscle-specific p130Cas-/-mice express the contractile proteins normally in skeletal muscle. Further-more, muscle-specific p130Cas-/-mice show normal mechanical-stress-induced muscle adaptation, including exercise-induced IIb-to-IIa muscle fiber type transformation and hypertrophy. Finally, we provide evidence that exercise-induced p38 MAPK signaling is not impaired by the muscle-specific deletion of p130Cas. We conclude that p130Cas plays a limited role in mechanical-stress-induced skel-etal muscle adaptation.
AB - Mammalian skeletal muscles undergo adaptation in response to changes in the functional demands upon them, involving mechanical-stress-induced cellular signaling called "mechanotransduction." We hypothesized that p130Cas, which is reported to act as a mechanosensor that transduces mechanical extension into cellular signaling, plays an important role in maintaining and promoting skeletal muscle adapta-tion in response to mechanical stress via the p38 MAPK signaling pathway. We demonstrate that muscle-specific p130Cas-/-mice express the contractile proteins normally in skeletal muscle. Further-more, muscle-specific p130Cas-/-mice show normal mechanical-stress-induced muscle adaptation, including exercise-induced IIb-to-IIa muscle fiber type transformation and hypertrophy. Finally, we provide evidence that exercise-induced p38 MAPK signaling is not impaired by the muscle-specific deletion of p130Cas. We conclude that p130Cas plays a limited role in mechanical-stress-induced skel-etal muscle adaptation.
KW - Mechanotransduction
KW - Muscle fiber type
KW - P38 MAPK
KW - Peroxisome proliferator-activated receptor-γ coactivator-1α
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U2 - 10.1152/ajpcell.00243.2012
DO - 10.1152/ajpcell.00243.2012
M3 - Article
VL - 304
JO - American Journal of Physiology - Cell Physiology
JF - American Journal of Physiology - Cell Physiology
SN - 0363-6143
IS - 6
ER -