Skeletal muscle adaptation in response to mechanical stress in p130cas-/-mice

Takayuki Akimoto, Kanako Okuhira, Katsuji Aizawa, Shogo Wada, Hiroaki Honda, Toru Fukubayashi, Takashi Ushida

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Mammalian skeletal muscles undergo adaptation in response to changes in the functional demands upon them, involving mechanical-stress-induced cellular signaling called "mechanotransduction." We hypothesized that p130Cas, which is reported to act as a mechanosensor that transduces mechanical extension into cellular signaling, plays an important role in maintaining and promoting skeletal muscle adapta-tion in response to mechanical stress via the p38 MAPK signaling pathway. We demonstrate that muscle-specific p130Cas-/-mice express the contractile proteins normally in skeletal muscle. Further-more, muscle-specific p130Cas-/-mice show normal mechanical-stress-induced muscle adaptation, including exercise-induced IIb-to-IIa muscle fiber type transformation and hypertrophy. Finally, we provide evidence that exercise-induced p38 MAPK signaling is not impaired by the muscle-specific deletion of p130Cas. We conclude that p130Cas plays a limited role in mechanical-stress-induced skel-etal muscle adaptation.

Original languageEnglish
Pages (from-to)C541-C547
JournalAmerican Journal of Physiology - Cell Physiology
Volume304
Issue number6
DOIs
Publication statusPublished - 2013 Jun 10
Externally publishedYes

Keywords

  • Mechanotransduction
  • Muscle fiber type
  • P38 MAPK
  • Peroxisome proliferator-activated receptor-γ coactivator-1α

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

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