Sleep spindles in human prefrontal cortex: An electrocorticographic study

Motoaki Nakamura, Sunao Uchida, Taketoshi Maehara, Kensuke Kawai, Nobuhide Hirai, Tetsuo Nakabayashi, Hiroshi Arakaki, Yoshiro Okubo, Toru Nishikawa, Hiroyuki Shimizu

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

To investigate the sleep spindle activity of the human prefrontal cortex (PFC), we simultaneously recorded whole nights of polysomnographic and electrocorticographic (ECoG) activities during the natural sleep of epileptic patients. Subjects were nine patients with intractable epilepsy who had subdural electrodes surgically attached to the orbital (seven cases), medial (three cases), or dorsolateral (two cases) PFC, and in one case to the frontal pole. To examine spindle frequencies, fast Fourier transformation (FFT) and auto-correlation analyses were performed on the PFC ECoG and Cz EEG data, primarily on epochs of stage 2 sleep. Lower sigma band ECoG oscillations of about 12 Hz were widely distributed across all prefrontal cortical areas including the frontal limbic regions, but none of the PFC sigma frequency peaks coincided with the faster (about 14 Hz) Cz EEG sleep spindles. Combining our results with anatomical and electrophysiological facts, it is suggested that the thalamofrontal circuit involving the rostral reticular and the mediodorsal nucleus of the thalamus is responsible for the generation of 12 Hz frontal spindles in humans.

Original languageEnglish
Pages (from-to)419-427
Number of pages9
JournalNeuroscience Research
Volume45
Issue number4
DOIs
Publication statusPublished - 2003 Apr 1
Externally publishedYes

Fingerprint

Prefrontal Cortex
Sleep
Electroencephalography
Mediodorsal Thalamic Nucleus
Sleep Stages
Thalamus
Human Activities
Electrodes

Keywords

  • Electrocorticogram
  • Epileptic
  • Human
  • Mediodorsal nucleus of the thalamus
  • Prefrontal cortex
  • Reticular nucleus of the thalamus
  • Sleep
  • Spindle oscillation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Nakamura, M., Uchida, S., Maehara, T., Kawai, K., Hirai, N., Nakabayashi, T., ... Shimizu, H. (2003). Sleep spindles in human prefrontal cortex: An electrocorticographic study. Neuroscience Research, 45(4), 419-427. https://doi.org/10.1016/S0168-0102(03)00007-5

Sleep spindles in human prefrontal cortex : An electrocorticographic study. / Nakamura, Motoaki; Uchida, Sunao; Maehara, Taketoshi; Kawai, Kensuke; Hirai, Nobuhide; Nakabayashi, Tetsuo; Arakaki, Hiroshi; Okubo, Yoshiro; Nishikawa, Toru; Shimizu, Hiroyuki.

In: Neuroscience Research, Vol. 45, No. 4, 01.04.2003, p. 419-427.

Research output: Contribution to journalArticle

Nakamura, M, Uchida, S, Maehara, T, Kawai, K, Hirai, N, Nakabayashi, T, Arakaki, H, Okubo, Y, Nishikawa, T & Shimizu, H 2003, 'Sleep spindles in human prefrontal cortex: An electrocorticographic study', Neuroscience Research, vol. 45, no. 4, pp. 419-427. https://doi.org/10.1016/S0168-0102(03)00007-5
Nakamura M, Uchida S, Maehara T, Kawai K, Hirai N, Nakabayashi T et al. Sleep spindles in human prefrontal cortex: An electrocorticographic study. Neuroscience Research. 2003 Apr 1;45(4):419-427. https://doi.org/10.1016/S0168-0102(03)00007-5
Nakamura, Motoaki ; Uchida, Sunao ; Maehara, Taketoshi ; Kawai, Kensuke ; Hirai, Nobuhide ; Nakabayashi, Tetsuo ; Arakaki, Hiroshi ; Okubo, Yoshiro ; Nishikawa, Toru ; Shimizu, Hiroyuki. / Sleep spindles in human prefrontal cortex : An electrocorticographic study. In: Neuroscience Research. 2003 ; Vol. 45, No. 4. pp. 419-427.
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