Sodium 1-(12-hydroxy)octadecanyl sulfate, an MMP2 inhibitor, isolated from a tunicate of the family polyclinidae

Masaki Fujita, Yoichi Nakao, Shigeki Matsunaga, Teruaki Nishikawa, Nobuhiro Fusetani

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Sodium 1-(12-hydroxy)octadecanyl sulfate (1) was isolated from a marine tunicate as a matrix metalloproteinase 2 (MMP2) inhibitor.1 The structure was elucidated by a combination of spectroscopic and chemical methods. Compound 1 inhibited MMP2 with an IC50 value of 9.0 μg/mL.

Original languageEnglish
Pages (from-to)1936-1938
Number of pages3
JournalJournal of Natural Products
Volume65
Issue number12
DOIs
Publication statusPublished - 2002 Dec 1
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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