Solubilization of dipropofol, an antibacterial agent, using saccharide and ascorbic acid

Masahiro Ogata, K. Oka, Masako Seki, Midori Hoshi, Hirokatsu Takatsu, Tadahiko Mashino, Shiro Urano, Toyoshige Endo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Dipropofol has a strong antibacterial activity against Gram-positive bacteria. However, it lacked the solubility in water and this property was supposed to limit its efficacy. We tried to improve the solubility and found a new solubilization method of dipropofol in water by the addition of a monosaccharide or ascorbic acid.

Original languageEnglish
Pages (from-to)1565-1568
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume30
Issue number8
DOIs
Publication statusPublished - 2007 Aug
Externally publishedYes

Fingerprint

Solubility
Ascorbic Acid
Anti-Bacterial Agents
Water
Monosaccharides
Gram-Positive Bacteria
dipropofol

Keywords

  • Ascorbic acid
  • Dipropofol
  • Monosaccharide
  • Solubilization

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Ogata, M., Oka, K., Seki, M., Hoshi, M., Takatsu, H., Mashino, T., ... Endo, T. (2007). Solubilization of dipropofol, an antibacterial agent, using saccharide and ascorbic acid. Biological and Pharmaceutical Bulletin, 30(8), 1565-1568. https://doi.org/10.1248/bpb.30.1565

Solubilization of dipropofol, an antibacterial agent, using saccharide and ascorbic acid. / Ogata, Masahiro; Oka, K.; Seki, Masako; Hoshi, Midori; Takatsu, Hirokatsu; Mashino, Tadahiko; Urano, Shiro; Endo, Toyoshige.

In: Biological and Pharmaceutical Bulletin, Vol. 30, No. 8, 08.2007, p. 1565-1568.

Research output: Contribution to journalArticle

Ogata, M, Oka, K, Seki, M, Hoshi, M, Takatsu, H, Mashino, T, Urano, S & Endo, T 2007, 'Solubilization of dipropofol, an antibacterial agent, using saccharide and ascorbic acid', Biological and Pharmaceutical Bulletin, vol. 30, no. 8, pp. 1565-1568. https://doi.org/10.1248/bpb.30.1565
Ogata, Masahiro ; Oka, K. ; Seki, Masako ; Hoshi, Midori ; Takatsu, Hirokatsu ; Mashino, Tadahiko ; Urano, Shiro ; Endo, Toyoshige. / Solubilization of dipropofol, an antibacterial agent, using saccharide and ascorbic acid. In: Biological and Pharmaceutical Bulletin. 2007 ; Vol. 30, No. 8. pp. 1565-1568.
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