Solubilization of dipropofol, an antibacterial agent, using saccharide and ascorbic acid

Masahiro Ogata, K. Oka, Masako Seki, Midori Hoshi, Hirokatsu Takatsu, Tadahiko Mashino, Shiro Urano, Toyoshige Endo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Dipropofol has a strong antibacterial activity against Gram-positive bacteria. However, it lacked the solubility in water and this property was supposed to limit its efficacy. We tried to improve the solubility and found a new solubilization method of dipropofol in water by the addition of a monosaccharide or ascorbic acid.

Original languageEnglish
Pages (from-to)1565-1568
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume30
Issue number8
DOIs
Publication statusPublished - 2007 Aug
Externally publishedYes

Keywords

  • Ascorbic acid
  • Dipropofol
  • Monosaccharide
  • Solubilization

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Ogata, M., Oka, K., Seki, M., Hoshi, M., Takatsu, H., Mashino, T., Urano, S., & Endo, T. (2007). Solubilization of dipropofol, an antibacterial agent, using saccharide and ascorbic acid. Biological and Pharmaceutical Bulletin, 30(8), 1565-1568. https://doi.org/10.1248/bpb.30.1565