Soluble β-amyloid induction of Alzheimer's phenotype for human fibroblast K+ channels

R. Etcheberrigaray, Etsuro Ito, C. S. Kim, D. L. Alkon

Research output: Contribution to journalArticle

172 Citations (Scopus)

Abstract

Although β-amyloid is the main constituent of neurite plaques and may play a role in the pathophysiology of Alzheimer's disease, mechanisms by which soluble β-amyloid might produce early symptoms such as memory loss before diffuse plaque deposition have not been implicated. Treatment of fibroblasts with β-amyloid (10 nM) induced the same potassium channel dysfunction previously shown to occur specifically in fibroblasts from patients with Alzheimer's disease-namely, the absence of a 113-picosiemen potassium channel. A tetraethylammonium-induced increase of intracellular concentrations of calcium, [Ca2+](i), a response that depends on functional 113-picosiemen potassium channels, was also eliminated or markedly reduced by 10 nM β-amyloid. Increased [Ca2+](i) induced by high concentrations of extracellular potassium and 166-picosiemen potassium channels were unaffected by 10 nM β-amyloid. In Alzheimer's disease, then, β-amyloid might alter potassium channels and thus impair neuronal function to produce symptoms such as memory loss by a means other than plaque formation.

Original languageEnglish
Pages (from-to)276-279
Number of pages4
JournalScience
Volume264
Issue number5156
Publication statusPublished - 1994
Externally publishedYes

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Amyloid
Potassium Channels
Fibroblasts
Phenotype
Alzheimer Disease
Memory Disorders
Tetraethylammonium
Neurites
Potassium
Calcium

ASJC Scopus subject areas

  • General

Cite this

Etcheberrigaray, R., Ito, E., Kim, C. S., & Alkon, D. L. (1994). Soluble β-amyloid induction of Alzheimer's phenotype for human fibroblast K+ channels. Science, 264(5156), 276-279.

Soluble β-amyloid induction of Alzheimer's phenotype for human fibroblast K+ channels. / Etcheberrigaray, R.; Ito, Etsuro; Kim, C. S.; Alkon, D. L.

In: Science, Vol. 264, No. 5156, 1994, p. 276-279.

Research output: Contribution to journalArticle

Etcheberrigaray, R, Ito, E, Kim, CS & Alkon, DL 1994, 'Soluble β-amyloid induction of Alzheimer's phenotype for human fibroblast K+ channels', Science, vol. 264, no. 5156, pp. 276-279.
Etcheberrigaray, R. ; Ito, Etsuro ; Kim, C. S. ; Alkon, D. L. / Soluble β-amyloid induction of Alzheimer's phenotype for human fibroblast K+ channels. In: Science. 1994 ; Vol. 264, No. 5156. pp. 276-279.
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