Spatially resolved measurement of wideband prompt gamma-ray emission toward on-line monitor for the future proton therapy

A. Koide, J. Kataoka, T. Taya, Y. Iwamoto, K. Sueoka, S. Mochizuki, M. Arimoto, T. Inaniwa

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    In proton therapy, the delivered dose should be monitored to a high degree of accuracy to avoid unnecessary exposure to healthy tissues and critical organs. Although positron emission tomography (PET) is most frequently used to verify the proton range, the nuclear reactions between protons and nuclei that generate positrons do not necessarily correspond to the actual proton range. Moreover, such imaging must be conducted after the treatment irradiation, because a PET gantry cannot be used in conjunction with a proton therapy beam. In this paper, we studied one-dimensional (1D) and two-dimensional (2D) distributions of prompt gamma rays of various energies, to determine the most suitable energy window for online monitoring in proton therapy. After an initial simulation study using the particle and heavy ion transport code system (PHITS), we irradiated a poly(methyl methacrylate) (PMMA) phantom with a 70-MeV proton beam to mimic proton range verification in a clinical situation. Using a newly developed Compton camera, we have experimentally confirmed for the first time that 4.4-MeV gamma rays emitted from 12C and 16O match the exact position of the Bragg peak in proton range verification.

    Original languageEnglish
    Pages (from-to)24-28
    Number of pages5
    JournalNuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
    Volume912
    DOIs
    Publication statusPublished - 2018 Dec 21

    Keywords

    • Compton camera
    • Particle therapy
    • Prompt gamma rays

    ASJC Scopus subject areas

    • Nuclear and High Energy Physics
    • Instrumentation

    Fingerprint Dive into the research topics of 'Spatially resolved measurement of wideband prompt gamma-ray emission toward on-line monitor for the future proton therapy'. Together they form a unique fingerprint.

  • Cite this