Spatially resolved measurement of wideband prompt gamma-ray emission toward on-line monitor for the future proton therapy

A. Koide, Jun Kataoka, T. Taya, Y. Iwamoto, K. Sueoka, S. Mochizuki, M. Arimoto, T. Inaniwa

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    In proton therapy, the delivered dose should be monitored to a high degree of accuracy to avoid unnecessary exposure to healthy tissues and critical organs. Although positron emission tomography (PET) is most frequently used to verify the proton range, the nuclear reactions between protons and nuclei that generate positrons do not necessarily correspond to the actual proton range. Moreover, such imaging must be conducted after the treatment irradiation, because a PET gantry cannot be used in conjunction with a proton therapy beam. In this paper, we studied one-dimensional (1D) and two-dimensional (2D) distributions of prompt gamma rays of various energies, to determine the most suitable energy window for online monitoring in proton therapy. After an initial simulation study using the particle and heavy ion transport code system (PHITS), we irradiated a poly(methyl methacrylate) (PMMA) phantom with a 70-MeV proton beam to mimic proton range verification in a clinical situation. Using a newly developed Compton camera, we have experimentally confirmed for the first time that 4.4-MeV gamma rays emitted from 12C and 16O match the exact position of the Bragg peak in proton range verification.

    Fingerprint

    Gamma rays
    monitors
    therapy
    Protons
    gamma rays
    broadband
    protons
    Positron emission tomography
    positrons
    tomography
    Proton beams
    Nuclear reactions
    gantry cranes
    Positrons
    Polymethyl methacrylates
    Heavy ions
    proton beams
    polymethyl methacrylate
    nuclear reactions
    organs

    Keywords

    • Compton camera
    • Particle therapy
    • Prompt gamma rays

    ASJC Scopus subject areas

    • Nuclear and High Energy Physics
    • Instrumentation

    Cite this

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    title = "Spatially resolved measurement of wideband prompt gamma-ray emission toward on-line monitor for the future proton therapy",
    abstract = "In proton therapy, the delivered dose should be monitored to a high degree of accuracy to avoid unnecessary exposure to healthy tissues and critical organs. Although positron emission tomography (PET) is most frequently used to verify the proton range, the nuclear reactions between protons and nuclei that generate positrons do not necessarily correspond to the actual proton range. Moreover, such imaging must be conducted after the treatment irradiation, because a PET gantry cannot be used in conjunction with a proton therapy beam. In this paper, we studied one-dimensional (1D) and two-dimensional (2D) distributions of prompt gamma rays of various energies, to determine the most suitable energy window for online monitoring in proton therapy. After an initial simulation study using the particle and heavy ion transport code system (PHITS), we irradiated a poly(methyl methacrylate) (PMMA) phantom with a 70-MeV proton beam to mimic proton range verification in a clinical situation. Using a newly developed Compton camera, we have experimentally confirmed for the first time that 4.4-MeV gamma rays emitted from 12C and 16O match the exact position of the Bragg peak in proton range verification.",
    keywords = "Compton camera, Particle therapy, Prompt gamma rays",
    author = "A. Koide and Jun Kataoka and T. Taya and Y. Iwamoto and K. Sueoka and S. Mochizuki and M. Arimoto and T. Inaniwa",
    year = "2017",
    month = "1",
    day = "1",
    doi = "10.1016/j.nima.2017.10.020",
    language = "English",
    journal = "Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment",
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    publisher = "Elsevier",

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    TY - JOUR

    T1 - Spatially resolved measurement of wideband prompt gamma-ray emission toward on-line monitor for the future proton therapy

    AU - Koide, A.

    AU - Kataoka, Jun

    AU - Taya, T.

    AU - Iwamoto, Y.

    AU - Sueoka, K.

    AU - Mochizuki, S.

    AU - Arimoto, M.

    AU - Inaniwa, T.

    PY - 2017/1/1

    Y1 - 2017/1/1

    N2 - In proton therapy, the delivered dose should be monitored to a high degree of accuracy to avoid unnecessary exposure to healthy tissues and critical organs. Although positron emission tomography (PET) is most frequently used to verify the proton range, the nuclear reactions between protons and nuclei that generate positrons do not necessarily correspond to the actual proton range. Moreover, such imaging must be conducted after the treatment irradiation, because a PET gantry cannot be used in conjunction with a proton therapy beam. In this paper, we studied one-dimensional (1D) and two-dimensional (2D) distributions of prompt gamma rays of various energies, to determine the most suitable energy window for online monitoring in proton therapy. After an initial simulation study using the particle and heavy ion transport code system (PHITS), we irradiated a poly(methyl methacrylate) (PMMA) phantom with a 70-MeV proton beam to mimic proton range verification in a clinical situation. Using a newly developed Compton camera, we have experimentally confirmed for the first time that 4.4-MeV gamma rays emitted from 12C and 16O match the exact position of the Bragg peak in proton range verification.

    AB - In proton therapy, the delivered dose should be monitored to a high degree of accuracy to avoid unnecessary exposure to healthy tissues and critical organs. Although positron emission tomography (PET) is most frequently used to verify the proton range, the nuclear reactions between protons and nuclei that generate positrons do not necessarily correspond to the actual proton range. Moreover, such imaging must be conducted after the treatment irradiation, because a PET gantry cannot be used in conjunction with a proton therapy beam. In this paper, we studied one-dimensional (1D) and two-dimensional (2D) distributions of prompt gamma rays of various energies, to determine the most suitable energy window for online monitoring in proton therapy. After an initial simulation study using the particle and heavy ion transport code system (PHITS), we irradiated a poly(methyl methacrylate) (PMMA) phantom with a 70-MeV proton beam to mimic proton range verification in a clinical situation. Using a newly developed Compton camera, we have experimentally confirmed for the first time that 4.4-MeV gamma rays emitted from 12C and 16O match the exact position of the Bragg peak in proton range verification.

    KW - Compton camera

    KW - Particle therapy

    KW - Prompt gamma rays

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