Specific RNA protease inhibitors from in vitro selection.

S. Yamamoto*, S. Saito, T. Tanaka, Yo Kikuchi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


RNA aptamers that bind to and inhibit the proteolytic activity of subtilisin BPN' are selected in vitro from pools of random RNA. The RNAs in vitro transcribed from the isolated clones show highly specific inhibition toward the microbial serine proteases. From the sequences of the isolated clones, a C/A-rich sequence was obtained. The kinetic features of the common C/A-rich sequence will be discussed.

Original languageEnglish
Pages (from-to)215-216
Number of pages2
JournalNucleic acids symposium series
Issue number42
Publication statusPublished - 1999
Externally publishedYes


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