Spectroscopic evaluation of glucose concentration in phosphate-buffered saline solution using principal component analysis

Atsushi Nakamura, Takeshi Hasegawa, Jujiro Nishijo, Masao Kanazawa, Katsuo Aizawa, Takayuki Sota

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Principal component analysis (PCA) has been used for quantitative analysis of infrared attenuated total reflection (ATR) spectra of chemical mixtures, so that the minute concentration of glucose in the chemical mixture would be evaluated. Spectroscopic calibration of chemical concentration has been, thus far, believed to require multidimensional least-squares methods, such as classical least squares (CLS) and partial least-squares (PLS) regression techniques. In the present study, however, the analysis of the infrared ATR spectra only by PCA has been found to be useful for the evaluation of concentration of specific minute species in a chemical mixture. The prediction accuracy by PCA only has proved to be comparable to that of PLS. The novel technique would enable us to measure the concentration of glucose in human blood with no invasion.

Original languageEnglish
JournalJapanese Journal of Applied Physics, Part 2: Letters
Volume41
Issue number4
Publication statusPublished - 2002 Apr 15

Fingerprint

principal components analysis
glucose
Principal component analysis
Glucose
phosphates
Phosphates
evaluation
Infrared radiation
least squares method
quantitative analysis
blood
regression analysis
Blood
Calibration
predictions
Chemical analysis

Keywords

  • Glucose concentration
  • Infrared attenuated total reflection
  • Loading vector
  • Principal component analysis
  • Score

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

Cite this

Spectroscopic evaluation of glucose concentration in phosphate-buffered saline solution using principal component analysis. / Nakamura, Atsushi; Hasegawa, Takeshi; Nishijo, Jujiro; Kanazawa, Masao; Aizawa, Katsuo; Sota, Takayuki.

In: Japanese Journal of Applied Physics, Part 2: Letters, Vol. 41, No. 4, 15.04.2002.

Research output: Contribution to journalArticle

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