Abstract
Striated muscle is well known to exist in either of two states-contraction or relaxation-under the regulation of Ca2+ concentration. Described here is a less well-known third, intermediate state induced under conditions of partial activation, known as SPOC (SPontaneous Oscillatory Contraction). This state is characterised by auto-oscillation between rapid-lengthening and slow-shortening phases. Notably, SPOC occurs in skinned muscle fibres and is therefore not the result of fluctuating Ca2+ levels, but is rather an intrinsic and fundamental phenomenon of the actomyosin motor. Summarised in this review are the experimental data on SPOC and its fundamental mechanism. SPOC presents a novel technique for studying independent communication and coordination between sarcomeres. In cardiac muscle, this auto-oscillatory property may work in concert with electro-chemical signalling to coordinate the heartbeat. Further, SPOC may represent a new way of demonstrating functional defects of sarcomeres in human heart failure.
| Original language | English |
|---|---|
| Pages (from-to) | 53-62 |
| Number of pages | 10 |
| Journal | Biophysical Reviews |
| Volume | 3 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2011 |
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Keywords
- Auto-oscillation
- Cardiac muscle
- Sarcomere
- Skeletal muscle
- SPOC
ASJC Scopus subject areas
- Biophysics
- Molecular Biology
- Structural Biology
Cite this
SPontaneous Oscillatory Contraction (SPOC) : Auto-oscillations observed in striated muscle at partial activation. / Wolfe, James Erle; Ishiwata, Shin'ichi; Braet, Filip; Whan, Renee; Su, Yingying; Lal, Sean; dos Remedios, Cristobal G.
In: Biophysical Reviews, Vol. 3, No. 2, 2011, p. 53-62.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - SPontaneous Oscillatory Contraction (SPOC)
T2 - Auto-oscillations observed in striated muscle at partial activation
AU - Wolfe, James Erle
AU - Ishiwata, Shin'ichi
AU - Braet, Filip
AU - Whan, Renee
AU - Su, Yingying
AU - Lal, Sean
AU - dos Remedios, Cristobal G.
PY - 2011
Y1 - 2011
N2 - Striated muscle is well known to exist in either of two states-contraction or relaxation-under the regulation of Ca2+ concentration. Described here is a less well-known third, intermediate state induced under conditions of partial activation, known as SPOC (SPontaneous Oscillatory Contraction). This state is characterised by auto-oscillation between rapid-lengthening and slow-shortening phases. Notably, SPOC occurs in skinned muscle fibres and is therefore not the result of fluctuating Ca2+ levels, but is rather an intrinsic and fundamental phenomenon of the actomyosin motor. Summarised in this review are the experimental data on SPOC and its fundamental mechanism. SPOC presents a novel technique for studying independent communication and coordination between sarcomeres. In cardiac muscle, this auto-oscillatory property may work in concert with electro-chemical signalling to coordinate the heartbeat. Further, SPOC may represent a new way of demonstrating functional defects of sarcomeres in human heart failure.
AB - Striated muscle is well known to exist in either of two states-contraction or relaxation-under the regulation of Ca2+ concentration. Described here is a less well-known third, intermediate state induced under conditions of partial activation, known as SPOC (SPontaneous Oscillatory Contraction). This state is characterised by auto-oscillation between rapid-lengthening and slow-shortening phases. Notably, SPOC occurs in skinned muscle fibres and is therefore not the result of fluctuating Ca2+ levels, but is rather an intrinsic and fundamental phenomenon of the actomyosin motor. Summarised in this review are the experimental data on SPOC and its fundamental mechanism. SPOC presents a novel technique for studying independent communication and coordination between sarcomeres. In cardiac muscle, this auto-oscillatory property may work in concert with electro-chemical signalling to coordinate the heartbeat. Further, SPOC may represent a new way of demonstrating functional defects of sarcomeres in human heart failure.
KW - Auto-oscillation
KW - Cardiac muscle
KW - Sarcomere
KW - Skeletal muscle
KW - SPOC
UR - http://www.scopus.com/inward/record.url?scp=84873133202&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873133202&partnerID=8YFLogxK
U2 - 10.1007/s12551-011-0046-7
DO - 10.1007/s12551-011-0046-7
M3 - Article
AN - SCOPUS:84873133202
VL - 3
SP - 53
EP - 62
JO - Biophysical Reviews
JF - Biophysical Reviews
SN - 1867-2450
IS - 2
ER -