Spontaneous regeneration of the central nervous system in gastropods

Ryota Matsuo, Etsuro Ito

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Of all organs in mammals including humans, the brain has the most limited regenerative capacity after injury or damage. In spite of extensive efforts to treat ischemic/stroke injury of the brain, thus far no reliable therapeutic method has been developed. However, some molluscan species show remarkable brain regenerative ability and can achieve full functional recovery following injury. The terrestrial pulmonates are equipped with a highly developed olfactory center, called the procerebrum, which is involved in olfactory discrimination and odor-aversion learning. Recent studies revealed that the procerebrum of the land slug can spontaneously recover structurally and functionally relatively soon after injury. Surprisingly, no exogenous interventions are required for this reconstitutive repair. The neurogenesis continues in the procerebrum in adult slugs as in the hippocampus and the olfactory bulb of mammals, and the reconstitutive regeneration seems to be mediated by enhanced neurogenesis. In this review, we discuss the relationship between neurogenesis and the regenerative ability of the brain, and also the evolutionary origin of the brain structures in which adult neurogenesis has been observed.

Original languageEnglish
Pages (from-to)35-42
Number of pages8
JournalBiological Bulletin
Volume221
Issue number1
Publication statusPublished - 2011 Aug 1
Externally publishedYes

Fingerprint

Gastropoda
Neurogenesis
neurogenesis
central nervous system
Regeneration
Central Nervous System
brain
Aptitude
Brain
slugs
Mammals
Wounds and Injuries
Olfactory Bulb
mammals
olfactory bulb
Brain Injuries
Hippocampus
hippocampus
stroke
Stroke

Keywords

  • LFP
  • Local field potential
  • PC
  • Procerebrum

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Spontaneous regeneration of the central nervous system in gastropods. / Matsuo, Ryota; Ito, Etsuro.

In: Biological Bulletin, Vol. 221, No. 1, 01.08.2011, p. 35-42.

Research output: Contribution to journalReview article

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