Stability of porphyrin-calix[4]arene complexes analyzed by electrospray ionization mass spectrometry

Satoshi Arai; Shinsuke Ishihara; Shinji Takeoka; Haruki Ohkawa; Toshimichi Shibue; Hiroyuki Nishide

doi:10.1002/rcm.1592

Stability of porphyrin-calix[4]arene complexes analyzed by electrospray ionization mass spectrometry

Satoshi Arai, Shinsuke Ishihara, Shinji Takeoka, Haruki Ohkawa, Toshimichi Shibue, Hiroyuki Nishide^*

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

The stability of some porphyrin-calix[4]arene sodium-ion complexes were determined by a collision-activated decomposition (CAD) method utilizing electrospray ionization mass spectrometry (ESI-MS). Comparing the values of E_1/2, the collision energy at which the relative intensity of the complex ion is 0.5, we found that the porphyrin-calix[4]arene complex with the higher value of E_1/2 corresponded to that with the larger association constant (K_ass), as measured by ¹H-NMR in CDCl ₃. Both our ESI-MS and NMR studies proved that the number of hydrogen bonds and the rigidity of the calix[4]arene stabilized the complex. The ESI-MS technique could be successful in screening the binding affinity in host-guest systems with a small amount of sample.

Original language	English
Pages (from-to)	2065-2068
Number of pages	4
Journal	Rapid Communications in Mass Spectrometry
Volume	18
Issue number	18
DOIs	https://doi.org/10.1002/rcm.1592
Publication status	Published - 2004 Sept 24

ASJC Scopus subject areas

Analytical Chemistry
Spectroscopy
Organic Chemistry

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abstract = "The stability of some porphyrin-calix[4]arene sodium-ion complexes were determined by a collision-activated decomposition (CAD) method utilizing electrospray ionization mass spectrometry (ESI-MS). Comparing the values of E1/2, the collision energy at which the relative intensity of the complex ion is 0.5, we found that the porphyrin-calix[4]arene complex with the higher value of E1/2 corresponded to that with the larger association constant (Kass), as measured by 1H-NMR in CDCl 3. Both our ESI-MS and NMR studies proved that the number of hydrogen bonds and the rigidity of the calix[4]arene stabilized the complex. The ESI-MS technique could be successful in screening the binding affinity in host-guest systems with a small amount of sample.",

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AU - Arai, Satoshi

AU - Ishihara, Shinsuke

AU - Takeoka, Shinji

AU - Ohkawa, Haruki

AU - Shibue, Toshimichi

AU - Nishide, Hiroyuki

PY - 2004/9/24

Y1 - 2004/9/24

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AB - The stability of some porphyrin-calix[4]arene sodium-ion complexes were determined by a collision-activated decomposition (CAD) method utilizing electrospray ionization mass spectrometry (ESI-MS). Comparing the values of E1/2, the collision energy at which the relative intensity of the complex ion is 0.5, we found that the porphyrin-calix[4]arene complex with the higher value of E1/2 corresponded to that with the larger association constant (Kass), as measured by 1H-NMR in CDCl 3. Both our ESI-MS and NMR studies proved that the number of hydrogen bonds and the rigidity of the calix[4]arene stabilized the complex. The ESI-MS technique could be successful in screening the binding affinity in host-guest systems with a small amount of sample.

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Stability of porphyrin-calix[4]arene complexes analyzed by electrospray ionization mass spectrometry

Abstract

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