Stem Cell Differentiation Toward the Myogenic Lineage for Muscle Tissue Regeneration

A Focus on Muscular Dystrophy

Serge Ostrovidov, Xuetao Shi, Ramin Banan Sadeghian, Sahar Salehi, Toshinori Fujie, Hojae Bae, Murugan Ramalingam, Ali Khademhosseini

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Skeletal muscle tissue engineering is one of the important ways for regenerating functionally defective muscles. Among the myopathies, the Duchenne muscular dystrophy (DMD) is a progressive disease due to mutations of the dystrophin gene leading to progressive myofiber degeneration with severe symptoms. Although current therapies in muscular dystrophy are still very challenging, important progress has been made in materials science and in cellular technologies with the use of stem cells. It is therefore useful to review these advances and the results obtained in a clinical point of view. This article focuses on the differentiation of stem cells into myoblasts, and their application in muscular dystrophy. After an overview of the different stem cells that can be induced to differentiate into the myogenic lineage, we introduce scaffolding materials used for muscular tissue engineering. We then described some widely used methods to differentiate different types of stem cell into myoblasts. We highlight recent insights obtained in therapies for muscular dystrophy. Finally, we conclude with a discussion on stem cell technology. We discussed in parallel the benefits brought by the evolution of the materials and by the expansion of cell sources which can differentiate into myoblasts. We also discussed on future challenges for clinical applications and how to accelerate the translation from the research to the clinic in the frame of DMD.

Original languageEnglish
Pages (from-to)866-884
Number of pages19
JournalStem Cell Reviews and Reports
Volume11
Issue number6
DOIs
Publication statusPublished - 2015 Dec 1

Fingerprint

Muscular Dystrophies
Regeneration
Cell Differentiation
Stem Cells
Myoblasts
Muscles
Duchenne Muscular Dystrophy
Tissue Engineering
Technology
Dystrophin
Muscular Diseases
Skeletal Muscle
Mutation
Therapeutics
Research
Genes

Keywords

  • DMD
  • Muscle
  • Muscular dystrophy
  • Scaffold
  • Stem cells
  • Tissue engineering

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology

Cite this

Ostrovidov, S., Shi, X., Sadeghian, R. B., Salehi, S., Fujie, T., Bae, H., ... Khademhosseini, A. (2015). Stem Cell Differentiation Toward the Myogenic Lineage for Muscle Tissue Regeneration: A Focus on Muscular Dystrophy. Stem Cell Reviews and Reports, 11(6), 866-884. https://doi.org/10.1007/s12015-015-9618-4

Stem Cell Differentiation Toward the Myogenic Lineage for Muscle Tissue Regeneration : A Focus on Muscular Dystrophy. / Ostrovidov, Serge; Shi, Xuetao; Sadeghian, Ramin Banan; Salehi, Sahar; Fujie, Toshinori; Bae, Hojae; Ramalingam, Murugan; Khademhosseini, Ali.

In: Stem Cell Reviews and Reports, Vol. 11, No. 6, 01.12.2015, p. 866-884.

Research output: Contribution to journalArticle

Ostrovidov, S, Shi, X, Sadeghian, RB, Salehi, S, Fujie, T, Bae, H, Ramalingam, M & Khademhosseini, A 2015, 'Stem Cell Differentiation Toward the Myogenic Lineage for Muscle Tissue Regeneration: A Focus on Muscular Dystrophy', Stem Cell Reviews and Reports, vol. 11, no. 6, pp. 866-884. https://doi.org/10.1007/s12015-015-9618-4
Ostrovidov, Serge ; Shi, Xuetao ; Sadeghian, Ramin Banan ; Salehi, Sahar ; Fujie, Toshinori ; Bae, Hojae ; Ramalingam, Murugan ; Khademhosseini, Ali. / Stem Cell Differentiation Toward the Myogenic Lineage for Muscle Tissue Regeneration : A Focus on Muscular Dystrophy. In: Stem Cell Reviews and Reports. 2015 ; Vol. 11, No. 6. pp. 866-884.
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