Abstract
Stereoselective construction of aldol adducts having tertiary alcohol at the α position was achieved via a titanium(IV) enolate derived from a lactate derivative with an Evans chiral auxiliary. The stereochemistry at α-tertiary alcohol could be controlled by selecting the protective group of the starting lactate.
| Original language | English |
|---|---|
| Pages (from-to) | 5249-5252 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 42 |
| Issue number | 31 |
| DOIs | |
| Publication status | Published - 2001 Jul 30 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
Cite this
Stereochemical control of tertiary alcohol : Aldol condensation of lactate derivatives. / Kamino, Tomoyuki; Murata, Yoshihisa; Kawai, Nobuyuki; Hosokawa, Seijiro; Kobayashi, Susumu.
In: Tetrahedron Letters, Vol. 42, No. 31, 30.07.2001, p. 5249-5252.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Stereochemical control of tertiary alcohol
T2 - Aldol condensation of lactate derivatives
AU - Kamino, Tomoyuki
AU - Murata, Yoshihisa
AU - Kawai, Nobuyuki
AU - Hosokawa, Seijiro
AU - Kobayashi, Susumu
PY - 2001/7/30
Y1 - 2001/7/30
N2 - Stereoselective construction of aldol adducts having tertiary alcohol at the α position was achieved via a titanium(IV) enolate derived from a lactate derivative with an Evans chiral auxiliary. The stereochemistry at α-tertiary alcohol could be controlled by selecting the protective group of the starting lactate.
AB - Stereoselective construction of aldol adducts having tertiary alcohol at the α position was achieved via a titanium(IV) enolate derived from a lactate derivative with an Evans chiral auxiliary. The stereochemistry at α-tertiary alcohol could be controlled by selecting the protective group of the starting lactate.
UR - http://www.scopus.com/inward/record.url?scp=0035974386&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035974386&partnerID=8YFLogxK
U2 - 10.1016/S0040-4039(01)00818-8
DO - 10.1016/S0040-4039(01)00818-8
M3 - Article
VL - 42
SP - 5249
EP - 5252
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 31
ER -