Stereochemical control of tertiary alcohol: Aldol condensation of lactate derivatives

Tomoyuki Kamino; Yoshihisa Murata; Nobuyuki Kawai; Seijiro Hosokawa; Susumu Kobayashi

doi:10.1016/S0040-4039(01)00818-8

Stereochemical control of tertiary alcohol: Aldol condensation of lactate derivatives

Tomoyuki Kamino, Yoshihisa Murata, Nobuyuki Kawai, Seijiro Hosokawa, Susumu Kobayashi

School of Advanced Science and Engineering

Research output: Contribution to journal › Article

25 Citations (Scopus)

Abstract

Stereoselective construction of aldol adducts having tertiary alcohol at the α position was achieved via a titanium(IV) enolate derived from a lactate derivative with an Evans chiral auxiliary. The stereochemistry at α-tertiary alcohol could be controlled by selecting the protective group of the starting lactate.

Original language	English
Pages (from-to)	5249-5252
Number of pages	4
Journal	Tetrahedron Letters
Volume	42
Issue number	31
DOIs	https://doi.org/10.1016/S0040-4039(01)00818-8
Publication status	Published - 2001 Jul 30

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ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Cite this

Kamino, T., Murata, Y., Kawai, N., Hosokawa, S., & Kobayashi, S. (2001). Stereochemical control of tertiary alcohol: Aldol condensation of lactate derivatives. Tetrahedron Letters, 42(31), 5249-5252. https://doi.org/10.1016/S0040-4039(01)00818-8

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Access to Document

10.1016/S0040-4039(01)00818-8