Stereochemical control of tertiary alcohol: Aldol condensation of lactate derivatives

Tomoyuki Kamino, Yoshihisa Murata, Nobuyuki Kawai, Seijiro Hosokawa, Susumu Kobayashi

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Stereoselective construction of aldol adducts having tertiary alcohol at the α position was achieved via a titanium(IV) enolate derived from a lactate derivative with an Evans chiral auxiliary. The stereochemistry at α-tertiary alcohol could be controlled by selecting the protective group of the starting lactate.

Original languageEnglish
Pages (from-to)5249-5252
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number31
DOIs
Publication statusPublished - 2001 Jul 30
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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