Stereochemical control of tertiary alcohol: Aldol condensation of lactate derivatives

Tomoyuki Kamino; Yoshihisa Murata; Nobuyuki Kawai; Seijiro Hosokawa; Susumu Kobayashi

doi:10.1016/S0040-4039(01)00818-8

Stereochemical control of tertiary alcohol: Aldol condensation of lactate derivatives

Tomoyuki Kamino, Yoshihisa Murata, Nobuyuki Kawai, Seijiro Hosokawa, Susumu Kobayashi

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Stereoselective construction of aldol adducts having tertiary alcohol at the α position was achieved via a titanium(IV) enolate derived from a lactate derivative with an Evans chiral auxiliary. The stereochemistry at α-tertiary alcohol could be controlled by selecting the protective group of the starting lactate.

Original language	English
Pages (from-to)	5249-5252
Number of pages	4
Journal	Tetrahedron Letters
Volume	42
Issue number	31
DOIs	https://doi.org/10.1016/S0040-4039(01)00818-8
Publication status	Published - 2001 Jul 30
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4039(01)00818-8

Fingerprint Dive into the research topics of 'Stereochemical control of tertiary alcohol: Aldol condensation of lactate derivatives'. Together they form a unique fingerprint.

Cite this

@article{eb8bdb89c48f4c1fa95a2a181a0d6970,

title = "Stereochemical control of tertiary alcohol: Aldol condensation of lactate derivatives",

abstract = "Stereoselective construction of aldol adducts having tertiary alcohol at the α position was achieved via a titanium(IV) enolate derived from a lactate derivative with an Evans chiral auxiliary. The stereochemistry at α-tertiary alcohol could be controlled by selecting the protective group of the starting lactate.",

author = "Tomoyuki Kamino and Yoshihisa Murata and Nobuyuki Kawai and Seijiro Hosokawa and Susumu Kobayashi",

year = "2001",

month = jul,

day = "30",

doi = "10.1016/S0040-4039(01)00818-8",

language = "English",

volume = "42",

pages = "5249--5252",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "31",

}

TY - JOUR

T1 - Stereochemical control of tertiary alcohol

T2 - Aldol condensation of lactate derivatives

AU - Kamino, Tomoyuki

AU - Murata, Yoshihisa

AU - Kawai, Nobuyuki

AU - Hosokawa, Seijiro

AU - Kobayashi, Susumu

PY - 2001/7/30

Y1 - 2001/7/30

N2 - Stereoselective construction of aldol adducts having tertiary alcohol at the α position was achieved via a titanium(IV) enolate derived from a lactate derivative with an Evans chiral auxiliary. The stereochemistry at α-tertiary alcohol could be controlled by selecting the protective group of the starting lactate.

AB - Stereoselective construction of aldol adducts having tertiary alcohol at the α position was achieved via a titanium(IV) enolate derived from a lactate derivative with an Evans chiral auxiliary. The stereochemistry at α-tertiary alcohol could be controlled by selecting the protective group of the starting lactate.

UR - http://www.scopus.com/inward/record.url?scp=0035974386&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035974386&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(01)00818-8

DO - 10.1016/S0040-4039(01)00818-8

M3 - Article

AN - SCOPUS:0035974386

VL - 42

SP - 5249

EP - 5252

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 31

ER -