Stereochemical control of tertiary alcohol

Aldol condensation of lactate derivatives

Tomoyuki Kamino, Yoshihisa Murata, Nobuyuki Kawai, Seijiro Hosokawa, Susumu Kobayashi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Stereoselective construction of aldol adducts having tertiary alcohol at the α position was achieved via a titanium(IV) enolate derived from a lactate derivative with an Evans chiral auxiliary. The stereochemistry at α-tertiary alcohol could be controlled by selecting the protective group of the starting lactate.

Original languageEnglish
Pages (from-to)5249-5252
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number31
DOIs
Publication statusPublished - 2001 Jul 30
Externally publishedYes

Fingerprint

Condensation
Lactic Acid
Alcohols
Derivatives
Stereochemistry
Titanium
3-hydroxybutanal

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Stereochemical control of tertiary alcohol : Aldol condensation of lactate derivatives. / Kamino, Tomoyuki; Murata, Yoshihisa; Kawai, Nobuyuki; Hosokawa, Seijiro; Kobayashi, Susumu.

In: Tetrahedron Letters, Vol. 42, No. 31, 30.07.2001, p. 5249-5252.

Research output: Contribution to journalArticle

Kamino, Tomoyuki ; Murata, Yoshihisa ; Kawai, Nobuyuki ; Hosokawa, Seijiro ; Kobayashi, Susumu. / Stereochemical control of tertiary alcohol : Aldol condensation of lactate derivatives. In: Tetrahedron Letters. 2001 ; Vol. 42, No. 31. pp. 5249-5252.
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